Your browser doesn't support javascript.
loading
Serum hexosaminidase and á-glucuronidase activities in infants: effects of age and sex
Mabe, P; Beck, M.
Afiliação
  • Mabe, P; Universidad de Chile. INTA. Unidad de Genética y Enfermedades Metabólicas. Santiago. CL
  • Beck, M; Universität Mainz. Biochemisches Labor-Kinderklinik. Mainz. DE
Braz. j. med. biol. res ; 36(3): 377-383, Mar. 2003. graf
Artigo em Inglês | LILACS | ID: lil-329461
Biblioteca responsável: BR1.1
ABSTRACT
We investigated the effect of age and sex on the serum activity of hexosaminidase (HEX) and á-glucuronidase (BGLU) in 275 normal term infants aged 12 h to 12 months. Up to six weeks of life, HEX was significantly higher in boys (P<=0.023). During the age period of 1-26 weeks, BGLU was also higher in boys, but differences were significant only at 2-6 and 7-15 weeks (P<=0.016). The developmental pattern of HEX and BGLU was sex dependent. HEX activity increased in both sexes from 4-7 days of life, reaching a maximum of 1.4-fold the birth value at 2-6 weeks of age in boys (P<0.001) and a maximum of 1.6-fold at 7-15 weeks in girls (P<0.001). HEX activity gradually decreased thereafter, reaching significantly lower levels at 27-53 weeks than during the first three days of life in boys (P = 0.002) and the same level of this age interval in girls. BGLU increased in both sexes from 4-7 days of age, showing a maximum increase at 7-15 weeks (3.3-fold in boys and 2.9-fold in girls, both P<0.001). Then BGLU decreased in boys to a value similar to that observed at 4-7 days of age. In girls, BGLU remained elevated until the end of the first year of life. These results indicate a variation of HEX and BGLU activities during the first year of life and a sex influence on their developmental pattern. This observation should be considered in the diagnosis of GM2 gangliosidosis and mucopolysaccharidosis type VII
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Beta-N-Acetil-Hexosaminidases / Beta-Glucosidase Limite: Feminino / Humanos / Lactente / Masculino / Recém-Nascido Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2003 Tipo de documento: Artigo País de afiliação: Chile / Alemanha Instituição/País de afiliação: Universidad de Chile/CL / Universität Mainz/DE

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Beta-N-Acetil-Hexosaminidases / Beta-Glucosidase Limite: Feminino / Humanos / Lactente / Masculino / Recém-Nascido Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2003 Tipo de documento: Artigo País de afiliação: Chile / Alemanha Instituição/País de afiliação: Universidad de Chile/CL / Universität Mainz/DE
...