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Alteración de la respuesta inmunológica sistémica en asociación con endometriosis, empleando un modelo de estudio animal / Changes in the systemic immunologic response in association with endometriosis using an animal model
Guerrero, Cesar Angel; Ortega, Felipe Vadillo; Barba, Rubén Tlapanco; Pizano, Lourdes Arriaga; Vásquez, Arturo Cérbulo; Jiménez, Marco Antonio González; Montoya, Jorge Beltrán.
Afiliação
  • Guerrero, Cesar Angel; Instituto Nacional de Perinatología. MX
  • Ortega, Felipe Vadillo; Instituto Nacional de Perinatología. MX
  • Barba, Rubén Tlapanco; Instituto Nacional de Perinatología. MX
  • Pizano, Lourdes Arriaga; Instituto Nacional de Perinatología. MX
  • Vásquez, Arturo Cérbulo; Instituto Nacional de Perinatología. MX
  • Jiménez, Marco Antonio González; Instituto Nacional de Perinatología. MX
  • Montoya, Jorge Beltrán; Instituto Nacional de Perinatología. MX
Ginecol. obstet. Méx ; 70(4): 171-181, abr. 2002.
Artigo em Espanhol | LILACS | ID: lil-331102
Biblioteca responsável: BR1.1
RESUMO

INTRODUCTION:

Endometriosis constitutes the growth of endometrial tissue in a place other than the uterine cavity. Its etiopathogenesis is unknown, although there is some evidence associating it with the decrease of cytotoxic activity in the immunological system.

OBJECTIVE:

Evaluating the relationship between the development of ectopic endometrial tissue and the immunological status, and enumerating lymphocyte subpopulations and cytokine synthesis in T lymphocytes, using a murine endometriosis model.

METHODOLOGY:

Spleen lymphocytes isolated from two study groups of 10 female mice of the Balb/c strain that had been submitted to the surgical implantation of autologous endometrial tissue in the peritoneal cavity, and sacrificed after 5 (group I) and 8 (group II) weeks, were incubated--or not--with PMA/lonomicine. Lymphocyte T numbers and their cytokine production were determined by flow cytometry.

RESULTS:

A lower dispersion of the ectopic tissue growth value was observed in group II (24 vs. 42). A smaller population of cytotoxic T lymphocytes and a greater IL-4 production in the stimulated cells of the study group (p < 0.05) were observed, as compared to the control group.

CONCLUSIONS:

The presence of endometrial tissue in the uterine cavity decreases the amount of cytotoxic T lymphocytes and increases IL-4 production in total T lymphocytes, suggesting a modulation of the systemic immunological response to TH-2.
Assuntos
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Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Linfócitos T / Subpopulações de Linfócitos T / Interleucinas / Interferon gama / Endometriose Tipo de estudo: Estudo prognóstico / Fatores de risco Limite: Animais Idioma: Espanhol Revista: Ginecol. obstet. Méx Assunto da revista: Ginecologia / Obstetrícia Ano de publicação: 2002 Tipo de documento: Artigo País de afiliação: México Instituição/País de afiliação: Instituto Nacional de Perinatología/MX
Buscar no Google
Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Linfócitos T / Subpopulações de Linfócitos T / Interleucinas / Interferon gama / Endometriose Tipo de estudo: Estudo prognóstico / Fatores de risco Limite: Animais Idioma: Espanhol Revista: Ginecol. obstet. Méx Assunto da revista: Ginecologia / Obstetrícia Ano de publicação: 2002 Tipo de documento: Artigo País de afiliação: México Instituição/País de afiliação: Instituto Nacional de Perinatología/MX
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