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A clinico-pathological study of Cushing's syndrome at the University Hospital of the West Indies and a review of the literature
Wright-Pascoe, R; Charles, C. F; Richards, R; Fletcher, P; Hanchard, B; Kelly, D.
Afiliação
  • Wright-Pascoe, R; University of the West Indies. Faculty of Medical of Medical Sciences. Departments of Medicine, Surgery, Radiology, Anaesthesia and Intensive Care. JM
  • Charles, C. F; University of the West Indies. Faculty of Medical of Medical Sciences. Departments of Medicine, Surgery, Radiology, Anaesthesia and Intensive Care. JM
  • Richards, R; University of the West Indies. Faculty of Medical of Medical Sciences. Departments of Medicine, Surgery, Radiology, Anaesthesia and Intensive Care. JM
  • Fletcher, P; University of the West Indies. Faculty of Medical of Medical Sciences. Departments of Medicine, Surgery, Radiology, Anaesthesia and Intensive Care. JM
  • Hanchard, B; University of the West Indies. Faculty of Medical of Medical Sciences. Departments of Medicine, Surgery, Radiology, Anaesthesia and Intensive Care. JM
  • Kelly, D; University of the West Indies. Faculty of Medical of Medical Sciences. Departments of Medicine, Surgery, Radiology, Anaesthesia and Intensive Care. JM
West Indian med. j ; 50(1): 55-61, Mar. 2001.
Artigo em Inglês | LILACS | ID: lil-333412
Biblioteca responsável: BR1.1
ABSTRACT
Cushing's syndrome is an uncommon but important disease. Twenty-one confirmed cases of spontaneous Cushing's syndrome were documented at the University Hospital of the West Indies over a 21-year period. They were predominantly young females (FM ratio of 174; mean age 25 years and 3 months). The commonest presenting symptoms were amenorrhoea (41) and obesity (19). Common clinical features were cushingnoid features (95), hypertension (76) and hirsutism (82). Twenty-nine per cent had frank hyperglycaemia. Cushing's syndrome was due to Cushing's disease in 10 cases, adrenal adenoma in 3 and adrenal carcinoma in 2 cases. In 4 cases with presumed adrenal hyperplasia, the histology was either unavailable or was not consistent with the diagnosis. Two cases appear now to have had the ectopic ACTH Syndrome. Adrenalectomy was the commonest treatment offered. There were no intra-operative or post-operative deaths but recurrence was common after subtotal adrenalectomy in Cushing's disease. Twenty-seven per cent of the patients developed Nelson's syndrome, which was fatal in 50. Long-term hormone replacement therapy was unnecessary after surgery for adrenal adenomas. Treatment of Cushing's syndrome was well tolerated by the patients.
Assuntos
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Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Síndrome de Cushing Limite: Adolescente / Adulto / Criança / Feminino / Humanos / Masculino País/Região como assunto: Caribe Idioma: Inglês Revista: West Indian med. j Assunto da revista: Medicina Ano de publicação: 2001 Tipo de documento: Artigo País de afiliação: Jamaica Instituição/País de afiliação: University of the West Indies/JM

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Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Síndrome de Cushing Limite: Adolescente / Adulto / Criança / Feminino / Humanos / Masculino País/Região como assunto: Caribe Idioma: Inglês Revista: West Indian med. j Assunto da revista: Medicina Ano de publicação: 2001 Tipo de documento: Artigo País de afiliação: Jamaica Instituição/País de afiliação: University of the West Indies/JM
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