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The feasibility of a porcine model of acute coronary occlusion and reperfusion using off-pump coronary artery bypass grafting
Brann, S. H; Thomas, C. N; Rose, S. S; Harperm, T; Chen, D; Ezeokoli, C; Cummings, P; Daniel, S.
Afiliação
  • Brann, S. H; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Thomas, C. N; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Rose, S. S; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Harperm, T; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Chen, D; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Ezeokoli, C; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Cummings, P; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
  • Daniel, S; University of the West Indies. Eric Williams Medical Sciences Complex. Cardiopulmonary Research Unit. TT
West Indian med. j ; 49(4): 271-275, Dec. 2000.
Artigo em Inglês | LILACS | ID: lil-333445
Biblioteca responsável: BR1.1
ABSTRACT
We developed an open-chest porcine model of acute coronary occlusion and surgical reperfusion, and attempted to prevent intra-operative ischaemic ventricular fibrillation (VF) by a Retrograde Intracoronary Glyceryl trinitrate (RIG) infusion into the occluded vessel. Five Yorkshire pigs (weight 50 +/- 1.1 kg), randomized into 3 groups, underwent median sternotomy under general anaesthesia. One pig (Group 1, control) underwent sternotomy and pericardiotomy only. Four pigs underwent acute left anterior descending (LAD) coronary occlusion. Two pigs were not reperfused (Group 2). Two pigs underwent surgical reperfusion (Group 3) via left internal mammary artery (LIMA) grafting to the LAD using the Off-Pump Coronary Artery Bypass (OPCAB) technique. Ischaemic injury was assessed using 7-lead electrocardiography (ECG) and transthoracic/epimyocardial echocardiography (ECHO). Group 1 transient intraoperative hypotension and VF occurred. Successful resuscitation and 10-week survival (until sacrifice) with normal left ventricular (LV) function was achieved. Group 2 there were ECG and ECHO evidence of acute LV ischaemic dysfunction in both pigs. The surviving pig had persistent anterior hypokinesis at 8 1/2 months. The other died intra-operatively following progressive ischaemic LV dysfunction despite resuscitative attempts. Group 3 the surviving pig had normal LV function at 8 months. Initial anterior LV akinesis normalized within 7 days. The other developed post-occlusion haemodynamic instability and died intra-operatively despite reperfusion. In this porcine model, acute LAD artery occlusion modified by the novel RIG infusion technique, followed by surgical reperfusion (OPCAB) is feasible. This model would facilitate further development of OPCAB surgical expertise and understanding of the pathophysiology of ischaemia-reperfusion injury.
Assuntos
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Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Suínos / Traumatismo por Reperfusão Miocárdica / Doença das Coronárias / Modelos Animais de Doenças / Anastomose de Artéria Torácica Interna-Coronária Limite: Animais / Humanos Idioma: Inglês Revista: West Indian med. j Assunto da revista: Medicina Ano de publicação: 2000 Tipo de documento: Artigo País de afiliação: Trinidad e Tobago Instituição/País de afiliação: University of the West Indies/TT

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Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Suínos / Traumatismo por Reperfusão Miocárdica / Doença das Coronárias / Modelos Animais de Doenças / Anastomose de Artéria Torácica Interna-Coronária Limite: Animais / Humanos Idioma: Inglês Revista: West Indian med. j Assunto da revista: Medicina Ano de publicação: 2000 Tipo de documento: Artigo País de afiliação: Trinidad e Tobago Instituição/País de afiliação: University of the West Indies/TT
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