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Estudio de algunas propiedades biológicas de 3 cepas de dengue 2 con diferencias en sus secuencias nucleotídicas / Study of various biological properties of 3 strains of dengue 2 with differences in their nucleotide sequences
Camacho, Daría Elena; Guzmán, María G; Morier, Luis; Alvarez, Mayling; Rodríguez, Rosmari; Comach, Guillermo.
Afiliação
  • Camacho, Daría Elena; Laboratorio Regional de diagnóstico e investigaciones del dengue y otras enfermedades virales. VE
  • Guzmán, María G; Instituto de Medicina Tropical Pedro Kouri. CU
  • Morier, Luis; Instituto de Medicina Tropical Pedro Kouri. CU
  • Alvarez, Mayling; Instituto de Medicina Tropical Pedro Kouri. CU
  • Rodríguez, Rosmari; Instituto de Medicina Tropical Pedro Kouri. CU
  • Comach, Guillermo; Laboratorio Regional de diagnóstico e investigaciones del dengue y otras enfermedades virales. VE
Rev. cuba. med. trop ; 51(3): 177-180, Sept.-Dec. 1999.
Artigo em Espanhol | LILACS | ID: lil-333512
Biblioteca responsável: BR1.1
RESUMO
Some biological properties of Dengue-2 strains such as A-15 (isolated in Cuba in 1981); Jamaica (isolated in Jamaica in 1981) and New Guinea "C" (NG"C") standard strain differing in their nucleotide sequences were studied. The results showed that the cytopathic effect in C6/36 HT cell line occurred earlier in A-15 strain and that fluorescence was first detected in Jamaica and A-15 strains. This seems to indicate that rapid detection of strains does not have any relation to neither their history of passage nor the original isolation system. A-15 and NG"C" strains exhibited an heterogeneous pattern formed by big and small plaques but average size of plaques in NG"C" was lower whereas Jamaica showed only small plaques. The most neurovirulent strain in mice was NG"G" followed by A-15 whereas Jamaica was not neurovirulent at all. These results indicate that A-15 has a different biological behaviour which is probably due to intrinsic differences. It should be taken into account that 7 amino acid changes were found in the envelope protein which may have affected the expression of some biological properties.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: DNA Viral / Vírus da Dengue Limite: Animais Idioma: Espanhol Revista: Rev. cuba. med. trop Assunto da revista: Medicina Tropical Ano de publicação: 1999 Tipo de documento: Artigo País de afiliação: Cuba / Venezuela Instituição/País de afiliação: Instituto de Medicina Tropical Pedro Kouri/CU / Laboratorio Regional de diagnóstico e investigaciones del dengue y otras enfermedades virales/VE

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: DNA Viral / Vírus da Dengue Limite: Animais Idioma: Espanhol Revista: Rev. cuba. med. trop Assunto da revista: Medicina Tropical Ano de publicação: 1999 Tipo de documento: Artigo País de afiliação: Cuba / Venezuela Instituição/País de afiliação: Instituto de Medicina Tropical Pedro Kouri/CU / Laboratorio Regional de diagnóstico e investigaciones del dengue y otras enfermedades virales/VE
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