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El receptor "pepenador" y su importancia en procesos amiloidáticos / The scavenger receptor and its importance in amyloid processes
Aguilar-Gaytán, Rocio; Mas-Oliva, Jaime.
Afiliação
  • Aguilar-Gaytán, Rocio; UNAM. Instituto de Fisiología Celular. MX
  • Mas-Oliva, Jaime; UNAM. Instituto de Fisiología Celular. MX
Gac. méd. Méx ; 138(5): 445-460, sep.-oct. 2002.
Artigo em Espanhol | LILACS | ID: lil-333691
Biblioteca responsável: BR1.1
RESUMO
The scavenger receptor (SRA or RPA) belongs to a wide family of receptor proteins. The classification is based on sequence homologies and structural similarities; nevertheless, it has been useful to group them on the basis of ligand specificity. The SRA was first identified as a receptor for modified low-density lipoproteins, where such modification permits to regulate the uptake of modified LDL by macrophages leading to a massive cholesterol accumulation. Moreover, SRA facilitates the clearance by phagocytic cells of microbial pathogens and senescent cells. SRA is a transmembrane glycoprotein that exists as a trimer comprised of a cystein-linker dimer and a non-covalently bound monomer. SRA has an a-helical coiled coil domain, which is essential for both trimer formation and acid-dependent ligand dissociation. It also contains a collagenous domain, essential for ligand binding. The majority of these ligands are polyanionic molecules, such as the A beta-peptide, important in the development of Alzheimer's disease. Present findings including our own consider that binding of these peptides to SRA activates an inflammatory response with the production of oxidative stress.
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Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Receptores Imunológicos / Amiloidose Limite: Humanos Idioma: Espanhol Revista: Gac. méd. Méx Assunto da revista: Medicina Ano de publicação: 2002 Tipo de documento: Artigo País de afiliação: México Instituição/País de afiliação: UNAM/MX

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Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Receptores Imunológicos / Amiloidose Limite: Humanos Idioma: Espanhol Revista: Gac. méd. Méx Assunto da revista: Medicina Ano de publicação: 2002 Tipo de documento: Artigo País de afiliação: México Instituição/País de afiliação: UNAM/MX
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