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Seroprevalence of Schistosoma mansoni in Puerto Ricans with inflammatory bowel disease
Torres, Esther A; Acosta, Héctor; Cruz, Marcia; Weinstock, Joel; Hillyer, George V.
Afiliação
  • Torres, Esther A; University of Puerto Rico. School of Medicine. Departments of Medicine and Pathology. Laboratory Medicine. San Juan. PR
  • Acosta, Héctor; University of Puerto Rico. School of Medicine. Departments of Medicine and Pathology. Laboratory Medicine. San Juan. PR
  • Cruz, Marcia; University of Puerto Rico. School of Medicine. Departments of Medicine and Pathology. Laboratory Medicine. San Juan. PR
  • Weinstock, Joel; University of Iowa. College of Medicine. Department of Medicine. Iowa City. US
  • Hillyer, George V; University of Puerto Rico. School of Medicine. Departments of Medicine and Pathology. Laboratory Medicine. San Juan. PR
P. R. health sci. j ; 20(3): 211-214, Sept. 2001.
Artigo em Inglês | LILACS | ID: lil-334050
Biblioteca responsável: BR1.1
RESUMO

BACKGROUND:

The etiology of Inflammatory Bowel Diseases, Crohn's disease (CD) and ulcerative colitis (UC), is unknown. These diseases have a higher incidence in industrialized countries and their pathogenesis involves an over-reaction of the immune system. A genetic factor is believed to predispose to the development of chronic inflammation in response to an unidentified stimulus. Exposure to infections in childhood may modulate future immune responses. Parasitosis, particularly Schistosomiasis, stimulate Th2 immune responses. It has been hypothesized that the absence of these parasitic infections, as seen in economically developed countries, favors a Th1 response that may result in the clinical appearance of Crohn's disease later in life.

OBJECTIVE:

To determine the prevalence of Schistosoma mansoni antibodies in Puerto Ricans with Inflammatory Bowel Disease and controls.

METHODS:

Serum from 92 Puerto Ricans with IBD and 106 controls was screened for S. mansoni adult microsomal antigens (MAMA) using the FASTELISA assay. Those positive were confirmed with an enzyme-linked immunoelectrotransfer blot test.

RESULTS:

Seven serum samples (3 UC and 4 controls) were positive for S. mansoni antibodies. There was no significant difference between groups in gender, municipality of origin or seroprevalence of Schistosomiasis. The control group was slightly older than the IBD group.

CONCLUSIONS:

Our study did not demonstrate an inverse relation between Schistosomiasis and IBD. However, the decreasing prevalence of Schistosomiasis in the general population of Puerto Rico may account for this result.
Assuntos
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Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Neglicenciadas Tema em saúde: Helmintíase / Esquistossomose / Zoonoses Base de dados: LILACS Assunto principal: Schistosoma mansoni / Esquistossomose mansoni / Doenças Inflamatórias Intestinais Tipo de estudo: Ensaio clínico controlado / Estudo de prevalência Limite: Animais / Feminino / Humanos / Masculino País/Região como assunto: Caribe / Porto Rico Idioma: Inglês Revista: P. R. health sci. j Assunto da revista: Medicina Ano de publicação: 2001 Tipo de documento: Artigo País de afiliação: Porto Rico / Estados Unidos Instituição/País de afiliação: University of Iowa/US / University of Puerto Rico/PR

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Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Neglicenciadas Tema em saúde: Helmintíase / Esquistossomose / Zoonoses Base de dados: LILACS Assunto principal: Schistosoma mansoni / Esquistossomose mansoni / Doenças Inflamatórias Intestinais Tipo de estudo: Ensaio clínico controlado / Estudo de prevalência Limite: Animais / Feminino / Humanos / Masculino País/Região como assunto: Caribe / Porto Rico Idioma: Inglês Revista: P. R. health sci. j Assunto da revista: Medicina Ano de publicação: 2001 Tipo de documento: Artigo País de afiliação: Porto Rico / Estados Unidos Instituição/País de afiliação: University of Iowa/US / University of Puerto Rico/PR
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