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Osteopenia in Puerto Ricans with Crohn's disease
Chinea, Betty; Rosa, Arnaldo; Oharriz, Juan J; Ramírez, M; Haddock, Lillian; Pérez, C; Torres, Esther A.
Afiliação
  • Chinea, Betty; University of Puerto Rico. School of Medicine. Department of Medicine. Gastroenterology Research Unit. San Juan. PR
  • Rosa, Arnaldo; University of Puerto Rico. School of Medicine. Department of Medicine. Gastroenterology Research Unit. San Juan. PR
  • Oharriz, Juan J; University of Puerto Rico. School of Medicine. Department of Medicine. Gastroenterology Research Unit. San Juan. PR
  • Ramírez, M; University of Puerto Rico. School of Medicine. Department of Medicine. Endocrinology Section. San Juan. PR
  • Haddock, Lillian; University of Puerto Rico. School of Medicine. Department of Medicine. Endocrinology Section. San Juan. PR
  • Pérez, C; University of Puerto Rico. Medical Sciences Campus. Graduate School of Public Health. Department of Biostatistics and Epidemiology. San Juan. PR
  • Torres, Esther A; University of Puerto Rico. School of Medicine. Department of Medicine. Gastroenterology Research Unit. San Juan. PR
P. R. health sci. j ; 19(4): 329-333, Dec. 2000.
Artigo em Inglês | LILACS | ID: lil-334085
Biblioteca responsável: BR1.1
RESUMO

BACKGROUND:

Osteopenia has been reported in association to Inflammatory Bowel Disease, and in particular Crohn's disease. The use of corticosteroids, resection of the ileum, malabsorption, poor calcium intake, and the effect of inflammatory cytokines have all been considered as contributing factors. As Crohn's disease is more prevalent in young people, when peak bone mass is achieved, the presence of osteopenia is especially significant.

OBJECTIVES:

The aim of this study was to evaluate the bone density of patients with Crohn's disease in the University of Puerto Rico IBD Clinic; to determine the prevalence of osteopenia in these patients and to correlate bone mineral density with risk factors for osteopenia.

METHODS:

Sixty-six patients, 30 males and 36 females were included. After informed consent, demographic, clinical and metabolic data was obtained. Serum albumin, calcium, inorganic phosphorus and alkaline phosphatase were measured. Body mass index (BMI) was calculated. Bone density was determined by DEXA of the lumbar spine and femur and expressed as the Z score (standard deviations from normal correlated with sex and age). Severe osteopenia was a Z score > or = -2 and osteopenia was Z < or = -1.99 or > or = 1.01. Results were expressed in means. Pearson correlation coefficient was used for quantitative variables and Pearson chi-square for categorical values.

RESULTS:

Osteopenia was present in the hip in 69 and in the lumbar spine in 68. Most patients had received steroids; the difference between treated and not treated patients was not significant. Osteopenia did not correlate with ileal resection, gender, BMI, disease characteristics or biochemical parameters.

CONCLUSIONS:

Low bone density was frequent in patients with Crohn's disease, but no specific risk factors could be identified. Bone density should be determined in patients with Crohn's disease in order to institute appropriate therapeutic measures.
Assuntos
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Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Doenças Ósseas Metabólicas / Doença de Crohn Tipo de estudo: Estudo de prevalência Limite: Adulto / Feminino / Humanos / Masculino País/Região como assunto: Caribe / Porto Rico Idioma: Inglês Revista: P. R. health sci. j Assunto da revista: Medicina Ano de publicação: 2000 Tipo de documento: Artigo País de afiliação: Porto Rico Instituição/País de afiliação: University of Puerto Rico/PR

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Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Doenças Ósseas Metabólicas / Doença de Crohn Tipo de estudo: Estudo de prevalência Limite: Adulto / Feminino / Humanos / Masculino País/Região como assunto: Caribe / Porto Rico Idioma: Inglês Revista: P. R. health sci. j Assunto da revista: Medicina Ano de publicação: 2000 Tipo de documento: Artigo País de afiliação: Porto Rico Instituição/País de afiliação: University of Puerto Rico/PR
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