Significant and transitory control of lesions development in mice immunized with a genomic library of Leishmania amazonensis
Rev. patol. trop
; 31(2): 245-248, jul.-dez. 2002. graf
Artigo
em Inglês
| LILACS
| ID: lil-363181
Biblioteca responsável:
BR584.1
ABSTRACT
DNA from a genomic library of Leishmania amazonensis and from pcDNA3 plasmid were used to immunize BALB/c mice. Three immunizations at two weeks intervals were done, with 50µg/0.1ml of DNA. A control group was also injected with the same volume of saline solution. Afterward, all mice were challenged with infective promastigotes of the parasite, and the development of lesions was followed during 16 weeks by dorsoventral measures of the footpad. Mice previously immunized with the genomic library were capable of controlling lesions at a significant level, with major significance between 9 and 13 weeks post challenge.
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Biblioteca Genômica
/
Vacinas de DNA
/
Leishmania
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. patol. trop
Assunto da revista:
Medicina Tropical
/
Patologia
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Cuba