Lanreotide and octreotide complexed with technetium-99m: labeling, stability and biodistribution studies
RBCF, Rev. bras. ciênc. farm. (Impr.)
; 40(1): 101-110, jan.-mar. 2004. ilus, tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-391018
Biblioteca responsável:
BR40.1
ABSTRACT
Lanreotide and Octreotide are cyclic octapeptide analogues of somatostatin that were labeled with the radioisotope Technetium-99m for use in diagnostic nuclear medicine. The peptides were processed in a tartrate/phthalate buffer solution containing reducing agent. The purpose of this investigation was to optimize direct labeling by varying some parameters, and to evaluate radiochemical stability and biodistribution in animals. The marked peptides were obtained with high labeling efficiency and no need for subsequent purification. best radiolabeling results corresponded to a molar ratio of SnCl2.H2O/peptide of 4.5. `ANTPOT. 99mTc'-peptides were radiochemically stable for 6 hours...
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Peptídeos
/
Octreotida
/
Tecnécio
/
Medicina Nuclear
Idioma:
Inglês
Revista:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Assunto da revista:
Bioquímica
/
Farmácia
/
Farmacologia
Ano de publicação:
2004
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Instituto de Pesquisas Energéticas e Nucleares/BR
/
Universidade Federal de São Paulo/BR
