Evaluation of the nitrergic myenteric neurons in the distal colon of diabetic rats treated with acetyl-L-Carnitine
Braz. j. morphol. sci
; 21(2): 105-110, Apr.-Jun. 2004. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-406363
Biblioteca responsável:
BR734.1
ABSTRACT
In this work, we evaluated the effect of acetyl-L-carnitine supplmentation on the presence of NADPH-diaphorase positive myenteric neurons in the distal colon of rats with diabetes mellitus induced by streptozotocin. Rats 105 days old were divided into four groups normoglycemic, normoglycemic supplemented with acetyl-L-carnitine, diabetic and diabetic supplemented with acetyl-L-carnitine. Diabetes was induced by the administration of streptozotocin (35 mg/kg, i. v.). Supplementation with acetyl-L-carnitine was done for 105 days. The neuronal density was similar in all groups. In diabetic rats, the area of neuronal cell body profile was greater (p<0, 05) than in normoglycemic rats, whereas in diabetic rats receiving acetyl-L-carnitine the areas were smaller than in the non-supplemented diabetic rats (p<0, 05). The increase in the colonic area of diabetic rats was greater than in diabetic rats treated with acetyl-L-carnitine (p<0, 05), indicating that the increment in the population of these neurons was higher in treated diabetic rats. These results suggest that the beneficial effect of carnitine is restricted to preventing an excessive increase in neuronal area. The greater dilatation of the distal colon seen in diabetic rats supplemented with acetyl-L-carnitine probably represents and adverse effect of this compound.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Acetilcarnitina
/
Diabetes Mellitus
/
NADPH Desidrogenase
/
Neurônios
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. morphol. sci
Assunto da revista:
Anatomia
Ano de publicação:
2004
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual Oeste do Paraná/BR
/
Universidade Estadual Paulista/BR
/
Universidade Estadual de Maringá/BR