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Immunochemical and morphometric features of astrocyte reactivity vs. plaque location in Alzheimer's disease
Vanzani, M. C; Iacono, R. F; Caccuri, R. L; Berria, M. I.
Afiliação
  • Vanzani, M. C; Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Buenos Aires. AR
  • Iacono, R. F; Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Buenos Aires. AR
  • Caccuri, R. L; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Buenos Aires. AR
  • Berria, M. I; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología. Buenos Aires. AR
Medicina (B.Aires) ; 65(3): 213-218, 2005. ilus, tab, graf
Artigo em Inglês | LILACS | ID: lil-425257
Biblioteca responsável: BR1.1
RESUMO
The quantitative relationship between glial fibrillary acidic protein (GFAP) hyper-reactivity and -amyloid protein (AP) deposition was investigated by double immunoperoxidase labeling of hippocampal and entorhinal cortex sections from five Alzheimer´s disease (AD) cases and five age-matched controls. AP plaques, which were absent in controls, were found in all AD samples, without significant differences in number or perimeter according to their location among the regions studied. In contrast, the mean number of GFAP (+) cells was significantly greater in the hippocampus than in the entorhinal cortex from AD cases (49 vs.39). Although at lower values (30 vs. 20), predominance of astrocyte hyperplasia in hippocampus as compared with entorhinal cortex was also found in control samples. Concomitant astrocyte hypertrophy, as defined by surface density (Sv) values of GFAP-immunoreactive material exceeding those of control means, affected a similar proportion of cells in the hippocampus (73%) and the entorhinal cortex (74%) from AD cases. Since an increased number of GFAP (+) cells in the hippocampus was not accompanied by an increased number and/or perimeter of neighbouring plaques, such differential hyper-reactivity in samples from AD patients, as well as in those with normal aging, seems to depend partially on the regional location of the involved astrocyte.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Envelhecimento / Astrócitos / Doença de Alzheimer Limite: Idoso / Humanos Idioma: Inglês Revista: Medicina (B.Aires) Assunto da revista: Medicina Ano de publicação: 2005 Tipo de documento: Artigo País de afiliação: Argentina Instituição/País de afiliação: Universidad de Buenos Aires/AR

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Envelhecimento / Astrócitos / Doença de Alzheimer Limite: Idoso / Humanos Idioma: Inglês Revista: Medicina (B.Aires) Assunto da revista: Medicina Ano de publicação: 2005 Tipo de documento: Artigo País de afiliação: Argentina Instituição/País de afiliação: Universidad de Buenos Aires/AR
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