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Iron homeostasis in the lung
Ghio, Andrew J; Turi, Jennifer L; Yang, Funmei; Garrick, Laura M; Garrick, Michael D.
Afiliação
  • Ghio, Andrew J; United States Environmental Protection Agency. US
  • Turi, Jennifer L; Duke University Medical Center. Durham. US
  • Yang, Funmei; University of Texas Health Science Center. Department of Cellular and Structural Biology. San Antonio. US
  • Garrick, Laura M; SUNY. Department of Biochemistry. Buffalo. US
  • Garrick, Michael D; SUNY. Department of Biochemistry. Buffalo. US
Biol. Res ; 39(1): 67-77, 2006. ilus, tab
Artigo em Inglês | LILACS | ID: lil-430699
Biblioteca responsável: BR1.1
ABSTRACT
Iron is essential for many aspects of cellular function. However, it also can generate oxygen-based free radicals that result in injury to biological molecules. For this reason, iron acquisition and distribution are tightly regulated. Constant exposure to the atmosphere results in significant exposure of the lungs to catalytically active iron. The lungs have a mechanism for detoxification to prevent associated generation of oxidative stress. Those same proteins that participate in iron uptake in the gut are also employed in the lung to transport iron intracellularly and sequester it in an inactive form within ferritin. The release of metal is expedited (as transferrin and ferritin) from lung tissue to the respiratory lining fluid for clearance by the mucocilliary pathway or to the reticuloendothelial system for long-term storage. This pathway is likely to be the major method for the control of oxidative stress presented to the respiratory tract.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Estresse Oxidativo / Células Epiteliais / Homeostase / Ferro / Pulmão Limite: Humanos Idioma: Inglês Revista: Biol. Res Assunto da revista: Biologia Ano de publicação: 2006 Tipo de documento: Artigo País de afiliação: Estados Unidos Instituição/País de afiliação: Duke University Medical Center/US / SUNY/US / United States Environmental Protection Agency/US / University of Texas Health Science Center/US
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Estresse Oxidativo / Células Epiteliais / Homeostase / Ferro / Pulmão Limite: Humanos Idioma: Inglês Revista: Biol. Res Assunto da revista: Biologia Ano de publicação: 2006 Tipo de documento: Artigo País de afiliação: Estados Unidos Instituição/País de afiliação: Duke University Medical Center/US / SUNY/US / United States Environmental Protection Agency/US / University of Texas Health Science Center/US
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