Hyperinsulinemic-euglycemic therapy for intoxication with calcium channel blockers
Bol. Asoc. Méd. P. R
; 97(3,Pt.2): 182-189, Jul.-Sept. 2005.
Artigo
em Inglês
| LILACS
| ID: lil-442768
Biblioteca responsável:
BR1.1
ABSTRACT
Conventional therapy for intoxication with calcium channel blockers consists of crystalloid solutions, calcium gluconate, glucagon and vasopressor agents. These therapies often fail to improve hemodynamic function in intoxicated patients. The pathophysologic mechanism proposed for intoxication with these agents, suggest hypoinsulinemia as the determinant factor. We will describe the case of a 77 years old man treated for an overdose of nifedipine and atenolol who arrived at our institution with hypotension and bradycardia. After conventional therapy failed to improve the patient's hemodynamic status, hyperinsulinemia and euglycemia contributed to the improvement of the patient's neurologic and hemodynamic condition. Thus, hyperinsulinemic-euglycemic therapy was of benefit in this patient with hemodynamic compromise secondary to intoxication with calcium channel blocker not responding to conventional therapy. We will review the mechanism of action of calcium channel blocker drugs as well as the clinical presentation and treatment options for calcium channel blocker intoxication.
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Atenolol
/
Glucagon
/
Bloqueadores dos Canais de Cálcio
/
Nifedipino
/
Glucose
/
Hiperinsulinismo
/
Hipoglicemiantes
/
Insulina
/
Antídotos
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Bol. Asoc. Méd. P. R
Assunto da revista:
Medicina
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Porto Rico
Instituição/País de afiliação:
Veterans Affairs Hospital/PR