Estatus inmunológico de las madres infectadas por T. cruzi / Immunological status of mothers infected with Trypanosoma cruzi
Rev. Soc. Bras. Med. Trop
; 38(supl.2): 101-104, 2005. graf
Article
em Es
| LILACS
| ID: lil-444165
Biblioteca responsável:
BR1.1
ABSTRACT
The mechanisms of congenital transmission of Chagas disease remain largely unknown. To better understand the role of maternal immunology during pregnancy in congenital Chagas transmission, we studied the cytokine production and the parasitic load in three groups of mothers infected mothers who transmitted the disease to their babies (M+B+-), infected mothers who did not transmit the disease to their babies (M+B-) and not infected mothers as a control group (M-B-). M+B+ mothers produced less IFNgamma and more IL-10 than the M+B- mothers, and they are not able to produce IL-2. M+B+ mothers showed a higher parasitic load. These results, indicated that the congenital Chagas transmission is associated with an immunological imbalance and a high parasitic load in the M+B+ mothers.
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Complicações Infecciosas na Gravidez
/
Trypanosoma cruzi
/
Citocinas
/
Doença de Chagas
/
Transmissão Vertical de Doenças Infecciosas
Limite:
Animals
/
Female
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Humans
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Pregnancy
Idioma:
Es
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
2005
Tipo de documento:
Article
/
Congress and conference
País de afiliação:
Bélgica
/
Bolívia