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Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium
Pejic, Snezana; Kasapovic, Jelena; Todorovic, Ana; Stojiljkovic, Vesna; Pajovic, Snezana B.
Afiliação
  • Pejic, Snezana; Vinca Institute of Nuclear Sciences. Laboratory of Molecular Biology and Endocrinology. Belgrade. RS
  • Kasapovic, Jelena; Vinca Institute of Nuclear Sciences. Laboratory of Molecular Biology and Endocrinology. Belgrade. RS
  • Todorovic, Ana; Vinca Institute of Nuclear Sciences. Laboratory of Molecular Biology and Endocrinology. Belgrade. RS
  • Stojiljkovic, Vesna; Vinca Institute of Nuclear Sciences. Laboratory of Molecular Biology and Endocrinology. Belgrade. RS
  • Pajovic, Snezana B; Vinca Institute of Nuclear Sciences. Laboratory of Molecular Biology and Endocrinology. Belgrade. RS
Biol. Res ; 39(4): 619-629, 2006. ilus, tab
Artigo em Inglês | LILACS | ID: lil-456597
Biblioteca responsável: BR1.1
ABSTRACT
Oxidative stress is considered to be involved in pathogenesis of many disorders of the female genital tract. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine diseases in order to evaluate the extent of oxidative stress in blood of such patients. Blood samples of healthy subjects and gynecological patients were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. The results show that alterations of measured parameters vary with the enzyme type and diagnosis. However, both reduction in antioxidants and elevation of lipid peroxidation were observed in general. Lipid hydroperoxides level was negatively correlated to superoxide dismutase and glutathione peroxidase activities, as well as positively correlated to catalase activity. In addition, the lipid hydroperoxides/ glutathione peroxidase ratio was found to be increased, according to the type of uterine disease. The obtained results show that perturbation of antioxidant status is more pronounced in blood of patients with premalignant (hyperplastic) and malignant (adenocarcinoma) lesions, compared to those with benign uterine changes such as polypus and myoma.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Oxirredutases / Neoplasias Uterinas / Peroxidação de Lipídeos / Hiperplasia Endometrial / Leiomioma / Antioxidantes Limite: Feminino / Humanos Idioma: Inglês Revista: Biol. Res Assunto da revista: Biologia Ano de publicação: 2006 Tipo de documento: Artigo / Documento de projeto Instituição/País de afiliação: Vinca Institute of Nuclear Sciences/RS

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Oxirredutases / Neoplasias Uterinas / Peroxidação de Lipídeos / Hiperplasia Endometrial / Leiomioma / Antioxidantes Limite: Feminino / Humanos Idioma: Inglês Revista: Biol. Res Assunto da revista: Biologia Ano de publicação: 2006 Tipo de documento: Artigo / Documento de projeto Instituição/País de afiliação: Vinca Institute of Nuclear Sciences/RS
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