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Ultrastructural evaluation of the radioprotective effect of sodium selenite on submandibular glands in rats
Pontual, Maria Luiza dos Anjos; Tuji, Fabrício Mesquita; Barros, Silvana Pereira; Bóscolo, Frab Norberto; Novaes, Pedro Duarte; Almeida, Solange Maria de.
Afiliação
  • Pontual, Maria Luiza dos Anjos; FederalUniversity of Paraíba. School of Dentistry. Department of Clinic and Social Dentistry. João Pessoa. BR
  • Tuji, Fabrício Mesquita; Federal University of Pará. Department of Oral Diagnosis. Belém. BR
  • Barros, Silvana Pereira; State University of Campinas. Dental School of Piracicaba. Department of Morphology. Piracicaba. BR
  • Bóscolo, Frab Norberto; State University of Campinas. Dental School of Piracicaba. Department of Oral Diagnosis. Piracicaba. BR
  • Novaes, Pedro Duarte; State University of Campinas. Dental School of Piracicaba. Department of Morphology. Piracicaba. BR
  • Almeida, Solange Maria de; State University of Campinas. Dental School of Piracicaba. Department of Oral Diagnosis. Piracicaba. BR
J. appl. oral sci ; 15(3): 162-168, May-June 2007.
Artigo em Inglês | LILACS-Express | LILACS | ID: lil-457277
Biblioteca responsável: BR1.1
ABSTRACT
The aim of this study was to evaluate the radioprotector effect of sodium selenite on the ultrastructure of submandibular glands in rats. Fifty-seven male albino Wistar rats were randomized to 4 groups control, irradiated, sodium selenite and irradiated/sodium selenite. The animals in the sodium selenite and irradiated/sodium selenite groups received intraperitoneal injections of sodium selenite (0.5 mg/kg body weight) 24 h before irradiation. The animals belonging to the irradiated and irradiated/sodium selenite groups were submitted to 15 Gy of gamma radiation in the head and neck region. The submandibular glands were removed at 4, 8, 12, 24, 48 and 72 h after irradiation. The ionizing radiation induced damage to the secretory cells, especially the serous cells, right from the first period. Vacuolization, lysis of cytoplasmic inclusions and nuclear alterations occurred. The sodium selenite group also presented cellular alterations in the study periods, but with less damage compared to that caused by radiation. There was greater similarity between the irradiated/sodium selenite group and the control group than with the other groups treated in all study periods. Despite the alterations observed in the sodium selenite group, sodium selenite presented a radioprotective action on the secretory cells of submandibular glands.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: J. appl. oral sci Assunto da revista: Odontologia Ano de publicação: 2007 Tipo de documento: Artigo / Documento de projeto País de afiliação: Brasil Instituição/País de afiliação: Federal University of Pará/BR / FederalUniversity of Paraíba/BR / State University of Campinas/BR

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: J. appl. oral sci Assunto da revista: Odontologia Ano de publicação: 2007 Tipo de documento: Artigo / Documento de projeto País de afiliação: Brasil Instituição/País de afiliação: Federal University of Pará/BR / FederalUniversity of Paraíba/BR / State University of Campinas/BR
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