Bacteria-induced apoptosis: an approach to bacterial pathogenesis
Braz. j. morphol. sci
; 23(1): 75-86, jan.-mar. 2006. ilus
Artigo
em Inglês
| LILACS
| ID: lil-467601
Biblioteca responsável:
BR734.1
ABSTRACT
Several pathogenic or opportunistic bacteria can induce or inhibit host cell apoptosis. The modulation of cellular pathways that results in the induction or delay of host cell apoptosis is an important mechanism of bacterial virulence. These processes can be mediated by various host cell signaling pathways that are subverted by the bacteria. Pathogens can activate apoptotic proteins such as caspases, inactivate anti-apoptotic proteins such as NFêB and mitogen-activated protein kinases, or up-regulate the endogenous receptor/ligand system that induces apoptosis, generally when the bacteria are bound to the host cell surface. Bacteria-induced apoptotic or anti-apoptotic processes are often related to the ability of the bacteria to reach the host tissues. However, since apoptosis is also involved in host defense mechanisms against infectious agents, this phenomenon apparently plays a central role in host-pathogen interactions.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Bactérias
/
Infecções Bacterianas
/
Células
/
Apoptose
/
Fator de Indução de Apoptose
Tipo de estudo:
Estudo de etiologia
Idioma:
Inglês
Revista:
Braz. j. morphol. sci
Assunto da revista:
Anatomia
Ano de publicação:
2006
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
State University of Campinas/BR