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Use of fibrin glue derived from snake venom in the repair of deep corneal ulcers: experimental study in dogs (Canis familiaris, Linnaeus, 1758)
Sampaio, R. L; Ranzani, J. J. T; Brandão, C. V. S; Thomazini-Santos, I. A; Barraviera, B; Barraviera, S. R. C. S; Giannini, M. J. S. M.
Afiliação
  • Sampaio, R. L; Uberaba University. School of Veterinary Medicine. Veterinary Hospital. Uberaba. BR
  • Ranzani, J. J. T; São Paulo State University. School of Veterinary Medicine and Animal Husbandry. Department of Veterinary Surgery. Botucatu. BR
  • Brandão, C. V. S; São Paulo State University. School of Veterinary Medicine and Animal Husbandry. Department of Veterinary Surgery. Botucatu. BR
  • Thomazini-Santos, I. A; UNESP. Botucatu Medical School. Blood Center. Laboratory of Hemostasis. Botucatu. BR
  • Barraviera, B; UNESP. Center for the Study of Venoms and Venomous Animals. Botucatu. BR
  • Barraviera, S. R. C. S; UNESP. FMB. Department of Dermatology and Radiotherapy. Botucatu. BR
  • Giannini, M. J. S. M; UNESP. Araraquara School of Pharmaceutical Sciences. Department of Clinical Analysis. Araraquara. BR
J. venom. anim. toxins incl. trop. dis ; 13(4): 857-873, 2007. ilus, graf
Artigo em Inglês | LILACS | ID: lil-471146
Biblioteca responsável: BR33.1
ABSTRACT
Fibrin glue has been researched as an alternative method for tissue synthesis and is known for its capability to promote hemostasis at the application site, good approximation of wound edges and fast healing. The current study consisted in the application of fibrin glue derived from snake venom as treatment for experimental corneal ulcers. Twenty-one dogs had their corneas experimentally prepared through lamellar keratectomy (of standardized diameter and depth). Animals were divided into seven groups of three animals each. Six experimental groups were periodically evaluated and collection was carried out on the 1st, 3rd, 7th, 15th, 30th and 60th post-operative days, whereas one control group was evaluated throughout the experiment. Analyses consisted in the clinical evolution and in the histopathological study of all operated on eyes. Results indicated that fibrin glue was efficient in repairing keratectomy wounds in dogs and contributed to an earlier healing phenomenon, avoiding edema formation and keeping corneal clearness. The use of fibrin glue derived from snake venom showed to be easy to apply, feasible with animal models and of low cost, avoiding the lesion progress and allowing fast and appropriate corneal healing.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Venenos de Serpentes / Adesivo Tecidual de Fibrina / Úlcera da Córnea Limite: Animais Idioma: Inglês Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: Toxicologia Ano de publicação: 2007 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: São Paulo State University/BR / UNESP/BR / Uberaba University/BR
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Venenos de Serpentes / Adesivo Tecidual de Fibrina / Úlcera da Córnea Limite: Animais Idioma: Inglês Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: Toxicologia Ano de publicação: 2007 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: São Paulo State University/BR / UNESP/BR / Uberaba University/BR
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