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In vitro anti-proliferation/cytotoxic activity of epingaione and its derivatives on the human SH-SY5Y neuroblastoma and TE-671 sarcoma cells
Williams, L. A; Conrad, J; Vogler, B; Rõsner, H; Porter, R. B; Setzer, W; Barton, E. N; Levy, H. G; Mika, S; Klaiber, I; Nkurunziza, JP; Kraus, W.
Afiliação
  • Williams, L. A; The University of Hohenheim. Institutes for Bio-organic Chemistry. DE
  • Conrad, J; s.af
  • Vogler, B; s.af
  • Rõsner, H; s.af
  • Porter, R. B; s.af
  • Setzer, W; s.af
  • Barton, E. N; s.af
  • Levy, H. G; s.af
  • Mika, S; s.af
  • Klaiber, I; s.af
  • Nkurunziza, JP; s.af
  • Kraus, W; s.af
West Indian med. j ; 56(1): 5-10, Jan. 2007.
Artigo em Inglês | LILACS | ID: lil-471845
Biblioteca responsável: BR1.1
ABSTRACT
Epingaione (4-Methyl-1-(5-methyl-2, 3,4,5-tetrahydro-[2,3']bifuranyl-5-yl)-pentan-2-one) was isolated as one of the major lipophilic secondary metabolites from the leaves and stems of Bontia daphnoides L. The compound gave 79.24and 50.83anti-proliferation/cytotoxic activity on the human SH-SY5Y neuroblastoma and TE-671 sarcoma cells in vitro at 50 pg/mL, respectively. Epingaione was transformed into eleven derivatives under laboratory conditions using ethanol, some gave greater anti-proliferation/cytotoxic activity on the cancer cell lines tested. One of the derivatives (compound 2) with enhanced cytotoxic activity was elucidated as 5'-Ethoxy-5-methyl-5-(4-methyl-2-oxo-pentyl)-2,3,4,5-tetrahydro-5'H-[2,3']bifuranyl-2'-one. Both epingaione and compound 2 caused an accumulation of arrested or dead SH-SY5Y neuroblastoma in the m-phase of the cell cycle as revealed by the m-phase specific marker KE 67.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Pentanonas / Sarcoma / Myoporaceae / Furanos / Fitoterapia / Neuroblastoma Limite: Humanos Idioma: Inglês Revista: West Indian med. j Assunto da revista: Medicina Ano de publicação: 2007 Tipo de documento: Artigo País de afiliação: Alemanha Instituição/País de afiliação: The University of Hohenheim/DE

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Pentanonas / Sarcoma / Myoporaceae / Furanos / Fitoterapia / Neuroblastoma Limite: Humanos Idioma: Inglês Revista: West Indian med. j Assunto da revista: Medicina Ano de publicação: 2007 Tipo de documento: Artigo País de afiliação: Alemanha Instituição/País de afiliação: The University of Hohenheim/DE
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