Prevalence of hemochromatosis in the Puerto Rico veteran population
P. R. health sci. j
; 26(2): 147-150, Jun. 2007.
Artigo
em Inglês
| LILACS
| ID: lil-476397
Biblioteca responsável:
BR1.1
ABSTRACT
BACKGROUND:
Hereditary hemochromatosis (HH) is a disorder of iron storage that results in iron overload. It's prevalence in Puerto Rico (PR) is unknown and the condition frequently undiagnosed.PURPOSE:
Determine the prevalence of HH in the PR Veteran population.METHODS:
Patients attending the San Juan VA Medical Center Laboratory for routine tests were invited to participate. Basic demographic data, symptoms related questionnaire, fasting samples for unbound iron binding capacity (UIBC) and serum iron were obtained. Transferrin saturation (TS) > or =45% was considered as iron overload. Patients with elevated TS had a second test done to confirm iron overload. Genetic testing was performed to patients with sustained elevated TS.RESULTS:
Data from 521 of the 559 recruited patients was available for analysis. 59 patients had TS > or =45%. Iron overload was confirmed in eleven patients. Two patients were lost to follow up; one had secondary causes for iron overload. Eight patients underwent genetic testing. Genetic mutations associated with hemochromatosis were found in four patients.CONCLUSION:
The estimated prevalence of confirmed iron overload in our population is 2%, similar to one in the United States, while the prevalence of genetic mutations associated to hemochromatosis is 0.76%, which is slightly higher. Both genetic mutations (C282Y, H63D) are equally seen in the evaluated population which is different from reports elsewhere. Physician awareness of the prevalence of HH in PR may result in increased screening and early identification of the condition.
Buscar no Google
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Hemocromatose
Tipo de estudo:
Estudo de prevalência
/
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Caribe
/
Porto Rico
Idioma:
Inglês
Revista:
P. R. health sci. j
Assunto da revista:
Medicina
Ano de publicação:
2007
Tipo de documento:
Artigo
País de afiliação:
Porto Rico
Instituição/País de afiliação:
VA Caribbean Healthcare System/PR