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Mortalidad intrahospitalaria en hombres y mujeres según terapias de reperfusión en infarto agudo del miocardio con supradesnivel del ST / ln-hospital mortality after ST-segment elevation myocardial infarction according to reperiusion therapy
Prieto, Juan Carlos; Sanhueza, Consuelo; Martínez, Nicolás; Nazzal, Carolina; Corbalán, Ramón; Cavada, Gabriel; Lanas, Fernando; Bartolucci, Jorge; Campos, Pabla.
Afiliação
  • Prieto, Juan Carlos; Universidad de Chile. Instituto de Ciencias Biomédicas. Programa de Farmacología Molecular y Clínica. Centro Cardiovascular Hospital Clínico. Santiago. CL
  • Sanhueza, Consuelo; Universidad de Chile. Instituto de Ciencias Biomédicas. Programa de Farmacología Molecular y Clínica. Centro Cardiovascular Hospital Clínico. Santiago. CL
  • Martínez, Nicolás; Universidad de Chile. Instituto de Ciencias Biomédicas. Programa de Farmacología Molecular y Clínica. Centro Cardiovascular Hospital Clínico. Santiago. CL
  • Nazzal, Carolina; Universidad de Chile. Facultad de Medicina. Escuela de Salud Pública. CL
  • Corbalán, Ramón; Pontificia Universidad Católica de Chile. Hospital Clínico. CL
  • Cavada, Gabriel; Universidad de Chile. Facultad de Medicina. Escuela de Salud Pública. CL
  • Lanas, Fernando; Universidad de La Frontera. Temuco. CL
  • Bartolucci, Jorge; Universidad de Los Andes. CL
  • Campos, Pabla; Hospital de Urgencias de la Asistencia Pública. CL
Rev. méd. Chile ; 136(2): 143-150, feb. 2008. tab
Artigo em Espanhol | LILACS | ID: lil-483232
Biblioteca responsável: BR1.1
ABSTRACT
Primary angioplasty is considered the best reperiusion therapy in the treatment of ST-segment elevation myocardial infarction (STEMI). However, thrombolysis is the reperiusion method most commonly used, due to its wide availability, reduced costs and ease of administration.

Aim:

To compare inhospital mortality in STEMI patients according to reperiusion therapy. Material and

Methods:

Patients admitted to Chilean hospitals participating in the GEMI network, from 2001 to 2005, with STEMI were included. They were divided in three groups a) treated with thrombolytics, b) treated with primary angioplasty, c) without reperiusion procedure. Inhospital mortality according to gender, was analized in each group, using a logistic regression method, to assess risk factors associated with mortality.

Results:

We included 3,255 patients. Global mortality was 9.9 percent (7.5 percent in men and 16.7 percent in women, p <0.001). Mortality in patients treated with thrombolytics, was 10.2 percent (7.6 percent in men and 18.7 percent in women, p <0.01). The figure for patients treated with primary angioplasty, was 4.7 percent (2.5 percent in men and 13 percent in women, p <0.01), and in patients without reperiusion, was 11.6 percent (9.8 percent in men and in 15.4 percent women, p <0.01). In each group women were older, had a higher prevalence of hypertension and a higher percentage of Killip 3-4 infarctions. Logistic regression showed that angioplasty, compared with no reperiusion, was associated with a reduced mortality only in men. The use oí thrombolytics in women was associated with a higher mortality.

Conclusions:

Primary angioplasty was the reperiusion therapy associated to the lower mortality in STEMI. Use of thrombolytics in women was associated with a higher mortality rate than in non reperfused women.
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Angioplastia Coronária com Balão / Terapia Trombolítica / Mortalidade Hospitalar / Infarto do Miocárdio Tipo de estudo: Ensaio clínico controlado Limite: Feminino / Humanos / Masculino Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 2008 Tipo de documento: Artigo País de afiliação: Chile Instituição/País de afiliação: Hospital de Urgencias de la Asistencia Pública/CL / Pontificia Universidad Católica de Chile/CL / Universidad de Chile/CL / Universidad de La Frontera/CL / Universidad de Los Andes/CL

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Angioplastia Coronária com Balão / Terapia Trombolítica / Mortalidade Hospitalar / Infarto do Miocárdio Tipo de estudo: Ensaio clínico controlado Limite: Feminino / Humanos / Masculino Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 2008 Tipo de documento: Artigo País de afiliação: Chile Instituição/País de afiliação: Hospital de Urgencias de la Asistencia Pública/CL / Pontificia Universidad Católica de Chile/CL / Universidad de Chile/CL / Universidad de La Frontera/CL / Universidad de Los Andes/CL
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