Avaliação da sensibilidade da citopatologia através de estudo comparativo com a colposcopia emportadoras de lesões cervicais induzidaspelo papilomavírus humano / Sensitivity evaluation of cytopathology by comparative study with colposcopy ininduced cervical lesion porters through human papillomavirus

RESUMO

O cancer cervical e o segundo mais comum entre mulheres no mundo e apresenta altas taxas de mortalidade feminina, tendo sido demonstrado o envolvimento do Papilomavirus humano (HPV) em 99,7% dos tumores cervicais. Realizou-se estudo retrospectivovisando avaliar a sensibilidade da citopatologia para lesoes cervicais associadas ao HPV, atraves de analise comparativa com a colposcopia, em mulheres atendidas em Clinica Privada da cidade de Natal – RN, no periodo de 2004 a 2007. Analisou-se 504 laudoscitopatologicos e colposcopicos. Os resultados demonstraram prevalencia da papilomavirose em 4,96% dos casos, para os dois metodos, na faixa etaria acima de 36 anos. Na citopatologia foi evidenciada associacao da virose com metaplasia escamosa (28%), lesoesintra-epiteliais de baixo grau – LSIL (4,37%), lesoes intra-epiteliais de alto grau - HSIL (0,60%) e atipias de significado indeterminado em celulas escamosas - ASC-US (0,40%). Quando comparados, os resultados apresentaram-se concordantes em 80% dos casos e discordantes em 20%. Conclui-se que a citopatologia apresentou alta sensibilidade para rastreamento das lesoes cervicais associadas ao HPV na clientela estudada.

ABSTRACT

Cervical cancer is the second most common type in women around the world, present high rate of feminine mortality, had been demonstrated an involvement of Human Papillomavirus (HPV) in 99,7% of cervical lesions. It was made a retrospective study focusing on sensitivity evaluation of cytopathology in cervical lesions with HPV association, through comparative analysis with colposcopy, in women patients of a Private Clinic at Natal – RN, from April 2004 to April 2007. 504 cytopathological and colposcopicalexams were analysed. The results shaw 4,96% of papillomavirus prevalence for both methods, mainly in patients older than 36 years. In cytopathology was evidenced events associated to squamous metaplasy (28%), Low-grade aquamous intraepithelial lesion –LSIL (4,37%), High-grade squamous intraepithelial lesion - HSIL (0,60%) and Atypical squamous cells of undetermined significance - ASC-US (0,40%). According the results, it was verified that 80% of cases were coincidents for cervical lesions by HPV with 20% of divergence. The present study concluded that cytopathology presented high sensitivity for cervical lesions associated to HPV investigationin studied customers.