Immunoexpression of p53 and p16 proteins as biomarkers in oral carcinogenesis
Appl. cancer res
; 29(2): 83-88, Apr.-June 2009. ilus, tab
Artigo
em Inglês
| LILACS, Inca
| ID: lil-547669
Biblioteca responsável:
BR30.1
ABSTRACT
Objective:
Defects in the cell cycle control system can lead to phenotype changes and consequently to the progression of oral cancer. Thus, the aim of this study was to analyze the immunohistochemical expression of p53 and p16 and their connection with hyperplastic and neoplastic progression. Materials andMethods:
Sixty-four histopathologic specimens were submitted to immunohistochemical technique to anti-p53 and anti-p16.Results:
This study showed a significant increase in the level of p53 in dysplasia and oral carcinomas. Regarding p16 immunoexpression, a decrease was observed in mild to moderate dysplasia, and remained consnt between moderate dysplasia to poorly differentiated carcinoma.Conclusion:
The study confirmed that the higher expression of p53 protein plays a significant role in tumor development and oral cancer progression, while the loss of p16 expression seems to be related only for the progression of carcinogenesis.Keywords Proteins. Immunohistochemical. Genes, p53. Genes, p16. Mouth. Neoplasms.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
/
Inca
Assunto principal:
Imuno-Histoquímica
/
Proteínas
/
Genes
/
Boca
/
Neoplasias
Limite:
Humanos
Idioma:
Inglês
Revista:
Appl. cancer res
Assunto da revista:
Neoplasias
Ano de publicação:
2009
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Graduate Student Universidade Positivo/BR
/
Universidade Positivo/BR