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Nuclear anomalies in the buccal cells of calcite factory workers
Diler, Songül Budak; Ergene, Serap.
Afiliação
  • Diler, Songül Budak; University of Nigde, Science and Letters. Nigde. TR
  • Ergene, Serap; University of Mersin, Science and Letters. Mersin. TR
Genet. mol. biol ; 33(2): 374-378, 2010. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: lil-548804
Biblioteca responsável: BR1.1
ABSTRACT
The micronucleus (MN) assay on exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans. To determine the genotoxic effects of calcite dust that forms during processing, MN assay was carried out in exfoliated buccal cells of 50 (25 smokers and 25 non-smokers) calcite factory workers and 50 (25 smokers and 25 non-smokers) age- and sex-matched control subjects. Frequencies of nuclear abnormalities (NA) other than micronuclei, such as binucleates, karyorrhexis, karyolysis and 'broken eggs', were also evaluated. Micronuclei and the other aforementioned anomalies were analysed by two way analysis of covariance. The linear correlations between the types of micronucleus and nuclear abnormalities were determined by Spearman's Rho. There was a positive correlation between micronuclei and other types of nuclear abnormalities in accordance with the Spearman's Rho test. Results showed statistically significant difference between calcite fabric workers and control groups. MN and NA frequencies in calcite fabric workers were significantly higher than those in control groups (p < 0.05). The results of this study indicate that calcite fabric workers are under risk of significant cytogenetic damage.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: Genet. mol. biol Assunto da revista: Genética Ano de publicação: 2010 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: University of Mersin, Science and Letters/TR / University of Nigde, Science and Letters/TR

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: Genet. mol. biol Assunto da revista: Genética Ano de publicação: 2010 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: University of Mersin, Science and Letters/TR / University of Nigde, Science and Letters/TR
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