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An investigation on in vitro and in vivo antimicrobial properties of the antidepressant: amitriptyline hydrochloride
Mandal, Anurup; Sinha, Chandrima; Jena, Aditya Kumar; Ghosh, Soma; Samanta, Amalesh.
Afiliação
  • Mandal, Anurup; Jadavpur University. Department of Pharmaceutical Technology. Division of Microbiology. Kolkata. IN
  • Sinha, Chandrima; Jadavpur University. Department of Pharmaceutical Technology. Division of Microbiology. Kolkata. IN
  • Jena, Aditya Kumar; Jadavpur University. Department of Pharmaceutical Technology. Division of Microbiology. Kolkata. IN
  • Ghosh, Soma; Jadavpur University. Department of Pharmaceutical Technology. Division of Microbiology. Kolkata. IN
  • Samanta, Amalesh; Jadavpur University. Department of Pharmaceutical Technology. Division of Microbiology. Kolkata. IN
Braz. j. microbiol ; 41(3): 635-642, Oct. 2010. graf, tab
Artigo em Inglês | LILACS | ID: lil-549405
Biblioteca responsável: BR32.1
ABSTRACT
The antidepressant drug amitriptyline hydrochloride was obtained in a dry powder form and was screened against 253 strains of bacteria which included 72 Gram positive and 181 Gram negative bacteria and against 5 fungal strains. The minimum inhibitory concentration (MIC) was determined by inoculating a loopful of an overnight peptone water culture of the organism on nutrient agar plates containing increasing concentrations of amitriptyline hydrochloride (0, 10 µg/mL, 25 µg/mL, 50 µg/mL, 100 µg/mL, 200 µg/mL). Amitriptyline hydrochloride exhibited significant action against both Gram positive and Gram negative bacteria at 25-200 µg/mL. In the in vivo studies it was seen that amitriptyline hydrochloride at a concentration of 25 µg/g and 30 µg/g body weight of mouse offered significant protection to Swiss strain of white mice when challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella typhimurium NCTC 74. The in vivo data were highly significant (p<0.001) according to the chi-square test.
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Infecções Bacterianas / Técnicas In Vitro / Resistência Microbiana a Medicamentos / Reação em Cadeia da Polimerase / Amitriptilina / Antibacterianos Limite: Animais / Humanos Idioma: Inglês Revista: Braz. j. microbiol Assunto da revista: Microbiologia Ano de publicação: 2010 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Jadavpur University/IN
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Infecções Bacterianas / Técnicas In Vitro / Resistência Microbiana a Medicamentos / Reação em Cadeia da Polimerase / Amitriptilina / Antibacterianos Limite: Animais / Humanos Idioma: Inglês Revista: Braz. j. microbiol Assunto da revista: Microbiologia Ano de publicação: 2010 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Jadavpur University/IN
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