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Participation of endogenous opioids in the antinociception induced by resistance exercise in rats
Galdino, G. S; Duarte, I. D. G; Perez, A. C.
Afiliação
  • Galdino, G. S; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Farmacologia. Belo Horizonte. BR
  • Duarte, I. D. G; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Farmacologia. Belo Horizonte. BR
  • Perez, A. C; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Farmacologia. Belo Horizonte. BR
Braz. j. med. biol. res ; 43(9): 906-909, Sept. 2010. ilus
Artigo em Inglês | LILACS | ID: lil-556855
Biblioteca responsável: BR1.1
ABSTRACT
Exercise is a low-cost intervention that promotes health and contributes to the maintenance of the quality of life. The present study was designed to investigate the influence of different resistance exercise protocols on the nociceptive threshold of rats. Female Wistar rats were used to perform exercises in a weight-lifting exercise model. The following groups were examined (N = 6 per group) untrained rats (control group); an acute protocol group consisting of rats submitted to 15 sets of 15 repetitions of resistance exercise (acute group); rats exercised with 3 sets of 10 repetitions, three times per week for 12 weeks (trained group), and a group consisting of trained rats that were further submitted to the acute protocol (trained-acute group). The nociceptive threshold was measured by the paw-withdrawal test, in which the withdrawal threshold (escape reaction) was measured by an apparatus applying force to the plantar surface of the animal paw. The opioid antagonist naloxone (2 mg/kg) was administered subcutaneously 10 min before the exercise protocols. The trained group demonstrated antinociception only up to day 45 of the 12-week training period. A significant increase (37 percent, P < 0.05) in the nociceptive threshold was produced immediately after exercise, decreasing to 15 percent after 15 min, when the acute exercise protocol was used. Naloxone reversed this effect. These data show that the acute resistance exercise protocol was effective in producing antinociception for 15 min. This antinociceptive effect is mediated by the activation of opioid receptors.
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Condicionamento Físico Animal / Limiar da Dor / Receptores Opioides / Treinamento de Força / Analgesia Aspecto: Preferência do paciente Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2010 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal de Minas Gerais/BR
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Condicionamento Físico Animal / Limiar da Dor / Receptores Opioides / Treinamento de Força / Analgesia Aspecto: Preferência do paciente Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2010 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal de Minas Gerais/BR
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