Transparencia en la investigación biomédica: A propósito de los riesgos asociados al uso de Avandia / Transparency in biomedical research: About the risks associated with the use of Avandia
Rev. méd. Chile
; 138(9): 1197-1200, sept. 2010.
Artigo
em Espanhol
| LILACS
| ID: lil-572029
Biblioteca responsável:
CL1.1
ABSTRACT
The question of how and when to communicate potential risks associated with new drugs has remained an important focus of tension between the pharmaceutical industry and regulatory entities, such as the American Food and Drug Administration. Recently there has been widespread concern related to the cardiovascular risks associated with the use of Avandia, a rosiglitazone produced by Glaxo Smith Kline. In fact, several metaanalyses involving rosiglitazone provided a relatively consistent message that rosiglitazone increases the risk of myocardial ischemic events. In the present article, we review the controversy regarding the way the pharmaceutical company handled this issue, and we describe examples of inappropriate conduct regarding an industry-sponsored clinical trial with this drug. We raise several important ethical questions related to the way researchers handle conflicts of interest when they are employees of the pharmaceutical industry. Finally, we discuss the requirements to conduct biomedical research funded by the pharmaceutical industry in Chile.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Doenças Cardiovasculares
/
Pesquisa Biomédica
/
Tiazolidinedionas
/
Indústria Farmacêutica
/
Hipoglicemiantes
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Aspecto:
Aspectos éticos
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2010
Tipo de documento:
Artigo