The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses
Braz. j. med. biol. res
; 44(4): 276-282, Apr. 2011. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-581490
Biblioteca responsável:
BR1.1
ABSTRACT
The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is rapidly induced after antigenic or inflammatory stimuli, and participates in the immunological synapse. Defects in the function of the SLAM-SAP pathway contribute to immunological abnormalities, resulting in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents. Initially, the role of SLAM was investigated using an anti-SLAM monoclonal antibody (α-SLAM mAb) identified as an agonist of the SLAM-SAP pathway, which could induce the production of interferon-γ and could redirect the immune response to a T helper 1 (Th1) cell profile. However, in this review we postulate that the SLAM-SAP pathway primarily induces a Th2 response and secondarily suppresses the Th1 response.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Ativação Linfocitária
/
Transdução de Sinais
/
Antígenos CD
/
Receptores de Superfície Celular
/
Peptídeos e Proteínas de Sinalização Intracelular
Tipo de estudo:
Revisão sistemática
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
FDC+BR
/
Instituto Federal de Educação, Ciência e Tecnologia do Ceará/BR
/
Universidade Federal do Ceará/BR