Predictors of low cardiac output in decompensated severe heart failure
Clinics
; 66(2): 239-244, 2011. graf, tab
Artigo
em Inglês
| LILACS
| ID: lil-581508
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVE:
To identify predictors of low cardiac output and mortality in decompensated heart failure.INTRODUCTION:
Introduction:
Patients with decompensated heart failure have a high mortality rate, especially those patients with low cardiac output. However, this clinical presentation is uncommon, and its management is controversial.METHODS:
We studied a cohort of 452 patients hospitalized with decompensated heart failure with an ejection fraction of <0.45. Patients underwent clinical-hemodynamic assessment and Chagas disease immunoenzymatic assay. Low cardiac output was defined according to L and C clinical-hemodynamic profiles. Multivariate analyses assessed clinical outcomes. P<0.05 was considered significant.RESULTS:
The mean age was 60.1 years; 245 (54.2 percent) patients were >60 years, and 64.6 percent were men. Low cardiac output was present in 281 (63 percent) patients on admission. Chagas disease was the cause of heart failure in 92 (20.4 percent) patients who had higher B type natriuretic peptide levels (1,978.38 vs. 1,697.64 pg/mL; P = 0.015). Predictors of low cardiac output were Chagas disease (RR 3.655, P<0.001), lower ejection fraction (RR 2.414, P<0.001), hyponatremia (RR 1.618, P = 0.036), and renal dysfunction (RR 1.916, P = 0.007). Elderly patients were inversely associated with low cardiac output (RR 0.436, P = 0.001). Predictors of mortality were Chagas disease (RR 2.286, P<0.001), ischemic etiology (RR 1.449, P = 0.035), and low cardiac output (RR 1.419, P = 0.047).CONCLUSIONS:
In severe decompensated heart failure, predictors of low cardiac output are Chagas disease, lower ejection fraction, hyponatremia, and renal dysfunction. Additionally, Chagas disease patients have higher B type natriuretic peptide levels and a worse prognosis independent of lower ejection fraction.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Doença de Chagas
/
Doenças Negligenciadas
/
Doença Cardiovascular
/
Doenças do Sistema Endócrino
/
Outras Doenças Circulatórias
Base de dados:
LILACS
Assunto principal:
Volume Sistólico
/
Baixo Débito Cardíaco
/
Doença de Chagas
/
Peptídeo Natriurético Encefálico
/
Insuficiência Cardíaca
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR