Your browser doesn't support javascript.
loading
Effect of glibenclamide on antinociceptive effects of antidepressants of different classes
Hajhashemi, Valiollah; Amin, Bahareh.
Afiliação
  • Hajhashemi, Valiollah; Isfahan University of Medical Sciences. School of Pharmacy and Pharmaceutical Sciences. Isfahan Pharmaceutical Sciences Research Center. Isfahan. IR
  • Amin, Bahareh; Isfahan University of Medical Sciences. School of Pharmacy and Pharmaceutical Sciences. Department of Pharmacology. Isfahan. IR
Clinics ; 66(2): 321-325, 2011. graf
Artigo em Inglês | LILACS | ID: lil-581521
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVES:

The purpose of this work was to determine whether the intraperitoneal administration of glibenclamide as a K ATP channel blocker could have an effect on the antinociceptive effects of antidepressants with different mechanisms of action.

METHODS:

Three antidepressant drugs, amitriptyline as a dual-action, nonselective inhibitor of noradrenaline and a serotonin reuptake inhibitor, fluvoxamine as a selective serotonin reuptake inhibitor and maprotiline as a selective noradrenaline reuptake inhibitor, were selected, and the effect of glibenclamide on their antinociceptive activities was assessed in male Swiss mice (25-30 g) using a formalin test.

DISCUSSION:

None of the drugs affected acute nociceptive responses during the first phase. Amitriptyline (5, 10 mg/ kg), maprotiline (10, 20 mg/kg) and fluvoxamine (20 and 30 mg/kg) effectively inhibited pain induction caused by the second phase of the formalin test. Glibenclamide (5 mg/kg) alone did not alter licking behaviors based on a comparison with the control group. However, the pretreatment of animals with glibenclamide (10 and 15 mg/kg) partially reversed the antinociceptive effects of fluvoxamine but not those of maprotiline. In addition, the highest dose of glibenclamide (15 mg/kg) partially prevented the analgesic effect of amitriptyline.

CONCLUSION:

Therefore, it seems that adenosine triphosphate-dependent potassium channels have a major role in the analgesic activity of amitriptyline and fluvoxamine.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Medição da Dor / Canais de Potássio / Glibureto / Bloqueadores dos Canais de Potássio / Analgésicos / Antidepressivos Limite: Animais Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2011 Tipo de documento: Artigo País de afiliação: Irã Instituição/País de afiliação: Isfahan University of Medical Sciences/IR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Medição da Dor / Canais de Potássio / Glibureto / Bloqueadores dos Canais de Potássio / Analgésicos / Antidepressivos Limite: Animais Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2011 Tipo de documento: Artigo País de afiliação: Irã Instituição/País de afiliação: Isfahan University of Medical Sciences/IR
...