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Insights into the transcriptome of oenocytes from Aedes aegypti pupae
Martins, Gustavo Ferreira; Ramalho-Ortigão, José Marcelo; Lobo, Neil Francis; Severson, David William; McDowell, Mary Ann; Pimenta, Paulo Filemon Paolucci.
Afiliação
  • Martins, Gustavo Ferreira; Universidade Federal de Viçosa. Departamento de Biologia Geral. Viçosa. BR
  • Ramalho-Ortigão, José Marcelo; Kansas State University. Department of Entomology. Manhattan. US
  • Lobo, Neil Francis; University of Notre Dame. Center for Global Health and Infectious Diseases. Department of Biological Sciences. Notre Dame. US
  • Severson, David William; University of Notre Dame. Center for Global Health and Infectious Diseases. Department of Biological Sciences. Notre Dame. US
  • McDowell, Mary Ann; University of Notre Dame. Center for Global Health and Infectious Diseases. Department of Biological Sciences. Notre Dame. US
  • Pimenta, Paulo Filemon Paolucci; Instituto René Rachou-Fiocruz. Laboratório de Entomologia Médica. Belo Horizonte. BR
Mem. Inst. Oswaldo Cruz ; 106(3): 308-315, May 2011. ilus
Artigo em Inglês | LILACS | ID: lil-589039
Biblioteca responsável: BR1.1
ABSTRACT
Oenocytes are ectodermic cells present in the fat body of several insect species and these cells are considered to be analogous to the mammalian liver, based on their role in lipid storage, metabolism and secretion. Although oenocytes were identified over a century ago, little is known about their messenger RNA expression profiles. In this study, we investigated the transcriptome of Aedes aegypti oenocytes. We constructed a cDNA library from Ae. aegypti MOYO-R strain oenocytes collected from pupae and randomly sequenced 687 clones. After sequences editing and assembly, 326 high-quality contigs were generated. The most abundant transcripts identified corresponded to the cytochrome P450 superfamily, whose members have roles primarily related to detoxification and lipid metabolism. In addition, we identified 18 other transcripts with putative functions associated with lipid metabolism. One such transcript, a fatty acid synthase, is highly represented in the cDNA library of oenocytes. Moreover, oenocytes expressed several immunity-related genes and the majority of these genes were lysozymes. The transcriptional profile suggests that oenocytes play diverse roles, such as detoxification and lipid metabolism, and increase our understanding of the importance of oenocytes in Ae. aegypti homeostasis and immune competence.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Negligenciadas Problema de saúde: Dengue Base de dados: LILACS Assunto principal: RNA Mensageiro / Genes de Insetos / DNA Complementar / Aedes / Metabolismo dos Lipídeos Limite: Animais Idioma: Inglês Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: Medicina Tropical / Parasitologia Ano de publicação: 2011 Tipo de documento: Artigo País de afiliação: Brasil / Estados Unidos Instituição/País de afiliação: Instituto René Rachou-Fiocruz/BR / Kansas State University/US / Universidade Federal de Viçosa/BR / University of Notre Dame/US

Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Negligenciadas Problema de saúde: Dengue Base de dados: LILACS Assunto principal: RNA Mensageiro / Genes de Insetos / DNA Complementar / Aedes / Metabolismo dos Lipídeos Limite: Animais Idioma: Inglês Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: Medicina Tropical / Parasitologia Ano de publicação: 2011 Tipo de documento: Artigo País de afiliação: Brasil / Estados Unidos Instituição/País de afiliação: Instituto René Rachou-Fiocruz/BR / Kansas State University/US / Universidade Federal de Viçosa/BR / University of Notre Dame/US
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