CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity
Biocell
; 34(2): 91-94, Aug. 2010. ilus, graf
Artigo
em Inglês
| LILACS
| ID: lil-595038
Biblioteca responsável:
AR40.1
ABSTRACT
CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Leucemia Mieloide
/
Movimento Celular
/
Extensões da Superfície Celular
Limite:
Humanos
Idioma:
Inglês
Revista:
Biocell
Assunto da revista:
Clulas
Ano de publicação:
2010
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
China Medical University/CN