Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank
Rev. bras. hematol. hemoter
; 33(2): 110-114, 2011. tab
Artigo
em Inglês
| LILACS
| ID: lil-596299
Biblioteca responsável:
BR408.1
ABSTRACT
BACKGROUND:
The study of platelet aggregation is essential to assess in vitro platelet function by different platelet activation pathways.OBJECTIVE:
To assess aggregation and biochemical parameters of random platelet concentrates produced at the Fundação HEMOAM using the quality control tests defined by law.METHODS:
Whole blood samples from 80 donors and the respective platelet concentrate units were tested. Platelet concentrates were tested (platelet count, aggregation and pH) on days 1, 3 and 5 of storage. Additionally a leukocyte count was done only on day 1 and microbiological tests on day 5 of storage. Collagen and adenosine diphosphate were used as inducing agonists for platelet aggregation testing.RESULTS:
Donor whole blood had normal aggregation (aggregation with adenosine diphosphate = 67 percent and with collagen = 78 percent). The median aggregation in platelet concentrates with adenosine diphosphate was low throughout storage (18 percent on day 1, 7 percent on day 3 and 6 percent on day 5) and the median aggregation with collagen was normal only on day 1 and low thereafter (54.4 percent on day 1, 20.5 percent on day 3 and 9 percent on day 5).CONCLUSION:
Although the results were within the norms required by law, platelet concentrates had low aggregation rates. We suggest the inclusion of a functional assessment test for the quality control of platelet concentrates for a more effective response to platelet replacement therapy.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Controle de Qualidade
/
Bancos de Sangue
/
Agregação Plaquetária
/
Transfusão de Componentes Sanguíneos
/
Hemostasia
Limite:
Animais
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2011
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Centro Universitário do Norte/BR
/
Fundação de Hematologia e Hemoterapia do Amazonas/BR
/
Fundação de Hematologia e Hemoterapia/BR