Ventricular fibrillation in acute experimental myocardial ischemia: protection by magnesium sulfate
Braz. j. med. biol. res
; 21(4): 791-9, 1988. ilus, tab
Article
em En
| LILACS
| ID: lil-60793
Biblioteca responsável:
BR26.1
RESUMO
The efficacy of magnesium sulfate for prevention of ventricular fibrillation was compared with that of the calcium blocker verapamil and other antiarrhythmic drugs in 54 open-chested anesthetized dogs during a 3-h ligation of the circumflex coronary artery. Latency time to fibrillation, incidence of fibrillation and hemodynamic parameters were assessed. 2. Ventricular fibrillation ocurred in 11 of 14(79%) control dogs, in 2 of 8(25%) dogs treated with magnesium sulfate (100 mg/Kg) and in none of 8 animals treated with verapamil (0.2 mg/Kg) (P = 0.014 and P = 0.0004, respectively, in comparison with controls); lidocaine (60 mg followed by 4 mg/min), amiodarone (5mg/kg) and propafenone (4mg/Kg) had no effect on the incidence of fibrillation. 3. The latency time to fibrillation was 11.6 ñ 9.1 min in controls and it was shortened to 4.0 ñ 3.8 min (P = 0.039) in dogs treated with propafenone, but was unaffected by other drugs. 4. There was no correlation between pre-occlusion heart rate or blood pressure and fibrillation incidence. 5. In this experimental model, magnesium sulfate infusion had a protective effect against ventricular fibrillation that was similar to verapamil, suggesting that magnesium sulfate may be useful as an antifibrillatory agent during acute ischemia
Buscar no Google
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Fibrilação Ventricular
/
Verapamil
/
Doença das Coronárias
/
Sulfato de Magnésio
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1988
Tipo de documento:
Article
/
Project document
País de publicação:
BR
/
BRASIL
/
BRASILE
/
BRAZIL
/
BRESIL