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Pituitary tumors in patients with MEN1 syndrome
Syro, Luis V.; Scheithauer, Bernd W.; Kovacs, Kalman; Toledo, Rodrigo A.; Londoño, Francisco J.; Ortiz, Leon D.; Rotondo, Fabio; Horvath, Eva; Uribe, Humberto.
Afiliação
  • Syro, Luis V.; Hospital Pablo Tobon Uribe. Clinica Medellin. Department of Neurosurgery. Medellin. CO
  • Scheithauer, Bernd W.; Mayo Clinic. Department of Laboratory Medicine and Pathology. Rochester. US
  • Kovacs, Kalman; University of Toronto. St. Michael's Hospital. Department of Laboratory Medicine. Toronto. CA
  • Toledo, Rodrigo A.; University of Sao Paulo. School of Medicine. Hospital das Clínicas. Endocrine Genetics Unit. Sao Paulo. BR
  • Londoño, Francisco J.; Universidad de Antioquia. Department of Neurosurgery.
  • Ortiz, Leon D.; Instituto de Cancerologia. Division of Neuro-oncology. Clinica Las Americas. Medellin. CO
  • Rotondo, Fabio; University of Toronto. St. Michael's Hospital. Department of Laboratory Medicine. Toronto. CA
  • Horvath, Eva; University of Toronto. St. Michael's Hospital. Department of Laboratory Medicine. Toronto. CA
  • Uribe, Humberto; Department of Neurosurgery. Clinica SOMA. Medellin. CO
Clinics ; 67(supl.1): 43-48, 2012.
Artigo em Inglês | LILACS | ID: lil-623130
Biblioteca responsável: BR1.1
ABSTRACT
We briefly review the characteristics of pituitary tumors associated with multiple endocrine neoplasia type 1. Multiple endocrine neoplasia type 1 is an autosomal-dominant disorder most commonly characterized by tumors of the pituitary, parathyroid, endocrine-gastrointestinal tract, and pancreas. A MEDLINE search for all available publications regarding multiple endocrine neoplasia type 1 and pituitary adenomas was undertaken. The prevalence of pituitary tumors in multiple endocrine neoplasia type 1 may vary from 10% to 60% depending on the studied series, and such tumors may occur as the first clinical manifestation of multiple endocrine neoplasia type 1 in 25% of sporadic and 10% of familial cases. Patients were younger and the time between initial and subsequent multiple endocrine neoplasia type 1 endocrine lesions was significantly longer when pituitary disease was the initial manifestation of multiple endocrine neoplasia type 1. Tumors were larger and more invasive and clinical manifestations related to the size of the pituitary adenoma were significantly more frequent in patients with multiple endocrine neoplasia type 1 than in subjects with non-multiple endocrine neoplasia type 1. Normalization of pituitary hypersecretion was much less frequent in patients with multiple endocrine neoplasia type 1 than in subjects with non-multiple endocrine neoplasia type 1. Pituitary tumors in patients with multiple endocrine neoplasia type 1 syndrome tend to be larger, invasive and more symptomatic, and they tend to occur in younger patients when they are the initial presentation of multiple endocrine neoplasia type 1.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Neoplasias Hipofisárias / Adenoma / Neoplasia Endócrina Múltipla Tipo 1 / Mutação Tipo de estudo: Fatores de risco Limite: Humanos Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2012 Tipo de documento: Artigo País de afiliação: Brasil / Canadá / Colômbia / Estados Unidos Instituição/País de afiliação: Department of Neurosurgery/CO / Hospital Pablo Tobon Uribe/CO / Instituto de Cancerologia/CO / Mayo Clinic/US / University of Sao Paulo/BR / University of Toronto/CA

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Neoplasias Hipofisárias / Adenoma / Neoplasia Endócrina Múltipla Tipo 1 / Mutação Tipo de estudo: Fatores de risco Limite: Humanos Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2012 Tipo de documento: Artigo País de afiliação: Brasil / Canadá / Colômbia / Estados Unidos Instituição/País de afiliação: Department of Neurosurgery/CO / Hospital Pablo Tobon Uribe/CO / Instituto de Cancerologia/CO / Mayo Clinic/US / University of Sao Paulo/BR / University of Toronto/CA
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