The role of thymic accessory cells in cytokine production and in the intra-thymic T cell differentiation pathway
Mem. Inst. Oswaldo Cruz
; 82(supl.2): 23-28, 1987. ilus, graf
Artigo
em Inglês
| LILACS
| ID: lil-623760
Biblioteca responsável:
BR1.1
ABSTRACT
Intrathymic T lymphocyte differentiation proceeds from complex interactions between prothymocytes of bone marrow origin and cells of the thymic stroma, epithelial cells and "acessory" cells (macrophages and/or interdigitating cells). The present paper describes the role of the accessoty cell compartment in this intrathymic process. Acessory cells produce factors which are involved in thymocyte proliferation (interleukin 1, prostaglandins, deoxynucleosides). Cell-cell interaction between "accessory" cells and thymocytes is required for the regulation of interleukin production. Prothymocytes, the precursors of all thymocyte subsets, need the accessory cell compartment for their IL2 dependent proliferation and their differentiation. Accessory cells of the thymic stroma may be involved in the intrathymic selection process at the prothymocyte level.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Fator Tímico Circulante
/
Receptores de Citocinas
Limite:
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
1987
Tipo de documento:
Artigo
/
Congresso e conferência
País de afiliação:
França
Instituição/País de afiliação:
INSERM U 25/FR