Atividade antimicrobiana de Tigeciclina frente a Cocos Gram-Positivos de importância clínica de Santa Maria-RS / Antimicrobial activity of tigecicline against clinical isolates of gram-positive coccus from Santa Maria - RS

RESUMO

As infecções causadas por microrganismos Gram-positivos têm sido e são um problema importante tanto nacomunidade como no âmbito hospitalar. Na era atual de redução no desenvolvimento de fármacos antimicrobianos, a Tigeciclina é a primeira das Glicilciclinas aprovadas para uso clínico pela FDA( ) que podeapresentar uma importante atividade contra estes microrganismos. Neste estudo, foram analisadas 131 amostras de cocos Gram-positivos provenientes de isolados clínicos de pacientes internados em um hospital privado de Santa Maria-RS. Para a determinação da atividade antimicrobiana de Tigeciclina utilizou-se o método de disco-difusão, onde foram dispostos discos de Tigeciclina nas placas contendo o meio de cultura Ágar Mueller Hinton. Os sítios anatômicos mais freqüentes deisolados clínicos foram urina com 44 amostras (33,6%), seguido de secreções com 22 amostras (16,8%), hemoculturas com 22 amostras (16,8%) e secreção traqueal com 12 amostras (9,2%). Os microrganismos mais freqüentemente isoladosforam com 87 amostras (66,4%), seguido de sp. com 19 amostras (14,5%), coagulase negativo com 8 amostras (6,1%), e com 7 amostras (5,4%). Quando verificada a atividade antimicrobiana de Tigeciclina, verificou-se que todas as amostras (100%) apresentaram susceptibilidade .Tigeciclina, Gram-positivos, atividade antimicrobiana. US Food and Drug Administration Staphylococcus aureus Streptococcus Staphylococcus aureus Staphylococcus epidermidis in vitro.

ABSTRACT

The infections caused by Gram-positive microorganisms have been and are an important problem in both thecommunity as well as the hospital extent. In the current era of reduction in the development of antimicrobial medicines, Tigecycline is the first of the Glycylcyclines approved to be clinically used by the FDA(US Food and Drug Administration) and it is capable of showing an important activity against those microorganisms. In this study, a total of 131 samples of Grampositivecocci excrement were tested and they were originating from clinical isolated cases of interned patients at a privatehospital in Santa Maria – RS. To determine the antimicrobial activity of Tigecycline, the disk diffusion method was used, where disks of Tigecycline were available in plates which contained the Mueller-Hinton Agar medium. The most frequent anatomical sites of clinical isolated cases were a total of 44 samples of urine (33, 6%), followed by 22 samples of secretions (16, 8%), 22 samples of hemoculture (16, 8%) and 12 samples of tracheal secretion (9, 2%). The most frequently isolatedmicroorganisms were a total of 87 samples of Staphylococcus aureus (66, 4%), followed by 19 samples of Streptococcus sp. (14, 5%), 8 samples of negative Staphylococcus aureus coagulose (6, 1%), and 7 samples of Staphylococcus epidermidis (5, 4%). When the antimicrobial activity of Tigecycline was verified, all the samples (100%) showed in vitro susceptibility.