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Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
Fernandes, Tania Rita Moreno de Oliveira; Santos, Itamar; Korinsfky, Juliana Pedrosa; Silva, Benedyto Savio Lima e; Carvalho, Luis Otavio; Plapler, Helio.
Afiliação
  • Fernandes, Tania Rita Moreno de Oliveira; Federal University of Sao Francisco Valley. Department of Medicine. Petrolina. BR
  • Santos, Itamar; Federal University of Sao Francisco Valley. Department of Medicine. Petrolina. BR
  • Korinsfky, Juliana Pedrosa; Federal University of Sao Francisco Valley. Nursing Department. Petrolina. BR
  • Silva, Benedyto Savio Lima e; Federal University of Sao Francisco Valley. Department of Medicine. Petrolina. BR
  • Carvalho, Luis Otavio; Oswaldo Cruz Institute Foundation. Histology Division. Rio de Janeiro. BR
  • Plapler, Helio; São Paulo Federal University. Paulista Medical School. São Paulo. BR
Acta cir. bras ; 29(1): 7-15, 01/2014. tab, graf
Artigo em Inglês | LILACS | ID: lil-697552
Biblioteca responsável: BR1.1
ABSTRACT

PURPOSE:

To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.

METHODS:

Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance.

RESULTS:

Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.

CONCLUSIONS:

Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation. .
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Praguicidas / Organofosfatos / Pele / Ferimentos e Lesões / Radiação Solar Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2014 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Federal University of Sao Francisco Valley/BR / Oswaldo Cruz Institute Foundation/BR / São Paulo Federal University/BR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Praguicidas / Organofosfatos / Pele / Ferimentos e Lesões / Radiação Solar Limite: Animais Idioma: Inglês Revista: Acta cir. bras Assunto da revista: CIRURGIA GERAL / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2014 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Federal University of Sao Francisco Valley/BR / Oswaldo Cruz Institute Foundation/BR / São Paulo Federal University/BR
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