Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide
Acta cir. bras
; 29(1): 7-15, 01/2014. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-697552
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.METHODS:
Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance.RESULTS:
Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.CONCLUSIONS:
Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation. .
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Praguicidas
/
Organofosfatos
/
Pele
/
Ferimentos e Lesões
/
Radiação Solar
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2014
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Federal University of Sao Francisco Valley/BR
/
Oswaldo Cruz Institute Foundation/BR
/
São Paulo Federal University/BR