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Predictive significance of standardized uptake value parameters of FDG-PET in patients with non-small cell lung carcinoma
Duan, X-Y.; Wang, W.; Li, M.; Li, Y.; Guo, Y-M..
Afiliação
  • Duan, X-Y.; The First Affiliated Hospital of Xi'an, Jiaotong University. PET-CT Center. Xi'an. CN
  • Wang, W.; The First Affiliated Hospital of Xi'an, Jiaotong University. PET-CT Center. Xi'an. CN
  • Li, M.; The First Affiliated Hospital of Xi'an, Jiaotong University. PET-CT Center. Xi'an. CN
  • Li, Y.; The First Affiliated Hospital of Xi'an, Jiaotong University. PET-CT Center. Xi'an. CN
  • Guo, Y-M.; The First Affiliated Hospital of Xi'an, Jiaotong University. PET-CT Center. Xi'an. CN
Braz. j. med. biol. res ; 48(3): 267-272, 03/2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-741252
Biblioteca responsável: BR1.1
ABSTRACT
18F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is widely used to diagnose and stage non-small cell lung cancer (NSCLC). The aim of this retrospective study was to evaluate the predictive ability of different FDG standardized uptake values (SUVs) in 74 patients with newly diagnosed NSCLC. 18F-FDG PET/CT scans were performed and different SUV parameters (SUVmax, SUVavg, SUVT/L, and SUVT/A) obtained, and their relationship with clinical characteristics were investigated. Meanwhile, correlation and multiple stepwise regression analyses were performed to determine the primary predictor of SUVs for NSCLC. Age, gender, and tumor size significantly affected SUV parameters. The mean SUVs of squamous cell carcinoma were higher than those of adenocarcinoma. Poorly differentiated tumors exhibited higher SUVs than well-differentiated ones. Further analyses based on the pathologic type revealed that the SUVmax, SUVavg, and SUVT/L of poorly differentiated adenocarcinoma tumors were higher than those of moderately or well-differentiated tumors. Among these four SUV parameters, SUVT/L was the primary predictor for tumor differentiation. However, in adenocarcinoma, SUVmax was the determining factor for tumor differentiation. Our results showed that these four SUV parameters had predictive significance related to NSCLC tumor differentiation; SUVT/L appeared to be most useful overall, but SUVmax was the best index for adenocarcinoma tumor differentiation.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Meta 3.9 Reduzir as mortes por produtos químicos y contaminação do ar, água e solo Problema de saúde: Exposições Ocupacionais Base de dados: LILACS Assunto principal: Fibrose Pulmonar / Exposição Ocupacional / Silicatos de Alumínio / Doenças Profissionais Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos / Masculino Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2015 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: The First Affiliated Hospital of Xi'an, Jiaotong University/CN

Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Meta 3.9 Reduzir as mortes por produtos químicos y contaminação do ar, água e solo Problema de saúde: Exposições Ocupacionais Base de dados: LILACS Assunto principal: Fibrose Pulmonar / Exposição Ocupacional / Silicatos de Alumínio / Doenças Profissionais Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos / Masculino Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2015 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: The First Affiliated Hospital of Xi'an, Jiaotong University/CN
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