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Studying inhibition of calcium oxalate stone formation: an in vitro approach for screening hydrogen sulfide and its metabolites
Vaitheeswari, S.; Sriram, R.; Brindha, P.; Kurian, Gino A..
Afiliação
  • Vaitheeswari, S.; SASTRA University. School of Chemical and Biotechnology. Thanjavur. IN
  • Sriram, R.; SASTRA University. School of Chemical and Biotechnology. Thanjavur. IN
  • Brindha, P.; SASTRA University. School of Chemical and Biotechnology. Thanjavur. IN
  • Kurian, Gino A.; SASTRA University. School of Chemical and Biotechnology. Thanjavur. IN
Int. braz. j. urol ; 41(3): 503-510, May-June 2015. ilus
Artigo em Inglês | LILACS | ID: lil-755866
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT<h2>Purpose:</h2>

Calcium oxalate urolithiasis is one of the most common urinary tract diseases and is of high prevalence. The present study proposes to evaluate the antilithiatic property of hydrogen sulfide and its metabolites like thiosulfate & sulfate in an in vitro model.

Materials and <h2>Methods:</h2>

The antilithiatic activity of sodium hydrogen sulfide (NaSH), sodium thiosulfate (Na2S2O3) and sodium sulfate (Na2SO4) on the kinetics of calcium oxalate crystal formation was investigated both in physiological buffer and in urine from normal and recurrent stone forming volunteers. The stones were characterized by optical and spectroscopic techniques.

<h2>Results:</h2>

The stones were characterized to be monoclinic, prismatic and bipyramidal habit which is of calcium monohydrate and dihydrate nature. The FTIR displayed fingerprint corresponding to calcium oxalate in the control while in NaSH treated, S=O vibrations were visible in the spectrum. The order of percentage inhibition was NaSH>Na2S2O3>Na2SO4.

<h2>Conclusion:</h2>

Our study indicates that sodium hydrogen sulfide and its metabolite thiosulfate are inhibitors of calcium oxalate stone agglomeration which makes them unstable both in physiological buffer and in urine. This effect is attributed to pH changes and complexing of calcium by S2O32-and SO42- moiety produced by the test compounds.

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Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Oxalato de Cálcio / Urolitíase / Sulfeto de Hidrogênio Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Fatores de risco / Estudo de rastreamento Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: SASTRA University/IN

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Oxalato de Cálcio / Urolitíase / Sulfeto de Hidrogênio Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico / Fatores de risco / Estudo de rastreamento Limite: Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: SASTRA University/IN
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