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Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus
Gur, Esra Bahar; Karadeniz, Muammer; Genc, Mine; Eskicioglu, Fatma; Yalcin, Murat; Hepyilmaz, Irem; Guclu, Serkan.
Afiliação
  • Gur, Esra Bahar; Sifa University. Faculty of Medicine. Department of Obstetrics and Gynecology. Izmir. TR
  • Karadeniz, Muammer; Sifa University. Faculty of Medicine. Department of Obstetrics and Gynecology. Izmir. TR
  • Genc, Mine; Sifa University. Faculty of Medicine. Department of Obstetrics and Gynecology. Izmir. TR
  • Eskicioglu, Fatma; Sifa University. Faculty of Medicine. Department of Obstetrics and Gynecology. Izmir. TR
  • Yalcin, Murat; Sifa University. Faculty of Medicine. Department of Obstetrics and Gynecology. Izmir. TR
  • Hepyilmaz, Irem; Sifa University. Faculty of Medicine. Department of Obstetrics and Gynecology. Izmir. TR
  • Guclu, Serkan; Sifa University. Faculty of Medicine. Department of Obstetrics and Gynecology. Izmir. TR
Arch. endocrinol. metab. (Online) ; 59(5): 448-454, Oct. 2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-764107
Biblioteca responsável: BR1.1
ABSTRACT
ObjectiveTo investigate whether vitamin D deficiency is associated with high mean platelet volume (MPV) in pregnancies diagnosed with gestational diabetes mellitus (GDM) compared to healthy pregnancies.Subjects and methodsThis study included 200 pregnant women. 25-hydroxyvitamin D3(25(OH)D3) and MPV values were monitored between pregnant women with GDM and normal glucose metabolism. Correlation between 25(OH)D3 and MPV was calculated both in GDM and healthy pregnancies. Both 25(OH)D3 level in different MPV percentile (≤ 50, 50-75, 75-90, ≥ 90 percentile) and MPV value in different 25(OH)D3 level (≤ 10, 10-20, ≥ 20 ng/mL) were calculated.ResultsLow 25(OH)D3 level and high MPV were observed both in GDM group (p = 0.007, p = 0.06, respectively) and in glucose metabolism disorders (GMD) group (p = 0.03, p = 0.04, respectively). There was no significant relationship between 25(OH)D3 and MPV in healthy pregnancies. Whereas, it is observed that there is a negative, but statistically insignificant correlation between MPV and 25(OH)D3 pregnant women with GMD (r = 0.1, r = -0.7, respectively). MPV values had significantly higher in vitamin D deficient group than pregnant women with normal 25(OH)D3 level in GMD group (p = 0.04). The optimal 25(OH)D3 cut off point for predicting future cardiovascular risk was 10.4 ng/ mL (area under curve (AUC) = 0.58).ConclusionsVitamin D deficiency may contribute to an increased risk for future cardiovascular diseases and a risk of thrombotic complications in pregnant women with GDM.
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Agenda de Saúde Sustentável para as Américas / ODS3 - Saúde e Bem-Estar Tema em saúde: Objetivo 9: Redução de doenças não transmissíveis / Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis Base de dados: LILACS Assunto principal: Deficiência de Vitamina D / Diabetes Gestacional / Volume Plaquetário Médio Limite: Adulto / Feminino / Humanos / Gravidez Idioma: Inglês Revista: Arch. endocrinol. metab. (Online) Assunto da revista: Endocrinologia / Metabolismo Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Sifa University/TR

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Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Agenda de Saúde Sustentável para as Américas / ODS3 - Saúde e Bem-Estar Tema em saúde: Objetivo 9: Redução de doenças não transmissíveis / Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis Base de dados: LILACS Assunto principal: Deficiência de Vitamina D / Diabetes Gestacional / Volume Plaquetário Médio Limite: Adulto / Feminino / Humanos / Gravidez Idioma: Inglês Revista: Arch. endocrinol. metab. (Online) Assunto da revista: Endocrinologia / Metabolismo Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Sifa University/TR
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