Evaluation of distal tubular function in aminoglycoside induced nephropathy
Braz. j. med. biol. res
; 20(6): 833-6, 1987. ilus, tab
Article
em En
| LILACS
| ID: lil-77463
Biblioteca responsável:
BR26.1
RESUMO
Acute metabolic acidosis potentiates the nephrotixicity of aminoglycosides by impairing the adequate excretion of ammonium and titratable acidity. The present study assesses distal tubular function after aminoglycoside administration in the rat. Two aminoglycosides, gentamicin and netilmicin were given to rats either in low doses equivalent to those used clinically (BG4 and BN5 groups) or in doses ten times higher (BG40 and BN50). The rats were subjected to acute metabolic alkalosis and the pCO2 of urine was continuously evaluated. the regression lines obtained by plotting the differences between urine and blood pCO2 as a function of urinary HCO3 in low dose models were simsilar to those obtained for the control group. However, the slopes obtained for BG40 and BN50 were significantly different from the control, suggesting an impairment of H+ secretion
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Acidose Tubular Renal
/
Gentamicinas
/
Netilmicina
/
Túbulos Renais
/
Túbulos Renais Distais
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1987
Tipo de documento:
Article
/
Congress and conference
/
Project document
País de publicação:
Brasil