Efecto del Capsicum annum L (pucunucho, ají mono) en úlcera gástrica experimental inducida en ratas / Effect of Capsicum annum L (pucunucho, ají mono) in gastric ulcer experimentally induced in rats

RESUMEN

Evaluar el efecto del extracto liofilizado del fruto de Capsicum annum L en úlcera gástrica experimental inducida en ratas. Materiales y métodos: Empleamos el modelo de úlcera gástrica inducida por indometacina y el modelo de úlcera gástrica inducida por ligadura del píloro en ratas separadas en 5 grupos de tratamiento G1 agua destilada 1 ml/Kg; G2 Ranitidina 50 mg/kg, G3 Capsicum 10 mg/kg, G4 Capsicum 100 mg/kg, G5 Capsicum 1000 mg/kg. Resultados: Los resultados del primer modelo muestran que a las dosis de 10 mg/Kg y 100 mg/Kg se obtuvo un porcentaje de inhibición de la lesión ulcerosa de 60,4% y 66,7% respectivamente; mientras que en el segundo modelo, el extracto no modificó el volumen gástrico ni en el pH gástrico (p >0,05); sin embargo a las dosis de 100 y 1000 mg/Kg la lesión ulcerosa se inhibió en 75,59% y 81,63% respectivamente; siendo además la inhibición mayor que con ranitidina (75,51%). Conclusiones: En conclusión demostramos que el extracto liofilizado del fruto de Capsicum annum L presenta efecto gastroprotector en úlcera gástrica experimental inducida en ratas...

ABSTRACT

To examine the effects of the Capsicum annum L lyophilized fruit extract in experimentally-induced gastric ulcer in rats. Materials and methods: We used the model of indomethacin gastric ulcer-induced and the gastric ulcer model induced by pylorus ligation in rats. The rats were divided in five treatment groups as follow G1 Distilled water 1 ml/Kg; G2 Ranitidine 50 mg/kg, G3 Capsicum 10mg/kg, G4 Capsicum 100 mg/kg, G5 Capsicum 1000 mg/kg. Results: The results of the first model showed an ulcer inhibition of 60,4% and 66,7% using the doses of Capsicum at 10 mg/kg and 100 mg/kg, respectively. The results of the second model showed that neither the pH nor the volume of the gastric content were modified by the administered extract (p >0.05); however, by using the doses of Capsicum at 100 mg/kg and 1000 mg/kg, there was clearly an ulcer inhibition of 75.59% and 81.63% respectively, which were even greater than the inhibition obtained by ranitidine (75.51%). Conclusions: Therefore, in this experiment we demonstrated that the Capsicum annum L lyophilized fruit extract has a gastroprotective effect in experimentally-induced gastric ulcer in rats...