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Angiotensin- (1-7) inhibits inflammation and oxidative stress to relieve lung injury induced by chronic intermittent hypoxia in rats
Lu, W; Kang, J; Hu, K; Tang, S; Zhou, X; Yu, S; Li, Y; Xu, L.
Afiliação
  • Lu, W; Renmin Hospital of Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Kang, J; Renmin Hospital of Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Hu, K; Renmin Hospital of Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Tang, S; Renmin Hospital of Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Zhou, X; Renmin Hospital of Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Yu, S; Renmin Hospital of Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Li, Y; Renmin Hospital of Wuhan University. Division of Respiratory Disease. Wuhan. CN
  • Xu, L; Renmin Hospital of Wuhan University. Division of Respiratory Disease. Wuhan. CN
Braz. j. med. biol. res ; 49(10): e5431, 2016. graf
Artigo em Inglês | LILACS | ID: lil-792525
Biblioteca responsável: BR1.1
ABSTRACT
Obstructive sleep apnea is associated with inflammation and oxidative stress in lung tissues and can lead to metabolic abnormalities. We investigated the effects of angiotensin1–7 [Ang-(1–7)] on lung injury in rats induced by chronic intermittent hypoxia (CIH). We randomly assigned 32 male Sprague-Dawley rats (180–200 g) to normoxia control (NC), CIH-untreated (uCIH), Ang-(1–7)-treated normoxia control (N-A), and Ang-(1–7)-treated CIH (CIH-A) groups. Oxidative stress biomarkers were measured in lung tissues, and expression of NADPH oxidase 4 (Nox4) and Nox subunits (p22phox, and p47phox) was determined by Western blot and reverse transcription-polymerase chain reaction. Pulmonary pathological changes were more evident in the uCIH group than in the other groups. Enzyme-linked immunosorbent assays and immunohistochemical staining showed that inflammatory factor concentrations in serum and lung tissues in the uCIH group were significantly higher than those in the NC and N-A groups. Expression of inflammatory factors was significantly higher in the CIH-A group than in the NC and N-A groups, but was lower than in the uCIH group (P<0.01). Oxidative stress was markedly higher in the uCIH group than in the NC and N-A groups. Expression of Nox4 and its subunits was also increased in the uCIH group. These changes were attenuated upon Ang-(1–7) treatment. In summary, treatment with Ang-(1-7) reversed signs of CIH-induced lung injury via inhibition of inflammation and oxidative stress.
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Fragmentos de Peptídeos / Vasodilatadores / Angiotensina I / Estresse Oxidativo / Lesão Pulmonar / Inflamação / Hipóxia Tipo de estudo: Estudo de avaliação Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2016 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Renmin Hospital of Wuhan University/CN

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Fragmentos de Peptídeos / Vasodilatadores / Angiotensina I / Estresse Oxidativo / Lesão Pulmonar / Inflamação / Hipóxia Tipo de estudo: Estudo de avaliação Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Assunto da revista: Biologia / Medicina Ano de publicação: 2016 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Renmin Hospital of Wuhan University/CN
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