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Physical stability and clinical efficacy of Crocodylus niloticus oil lotion
Venter, Telanie; Fox, Lizelle Triféna; Gerber, Minja; du Preez, Jan L.; van Zyl, Sterna; Boneschans, Banie; du Plessis, Jeanetta.
Afiliação
  • Venter, Telanie; North-West University. Faculty of Health Sciences. Centre of Excellence for Pharmaceutical Sciences. Potchefstroom. ZA
  • Fox, Lizelle Triféna; North-West University. Faculty of Health Sciences. Centre of Excellence for Pharmaceutical Sciences. Potchefstroom. ZA
  • Gerber, Minja; North-West University. Faculty of Health Sciences. Centre of Excellence for Pharmaceutical Sciences. Potchefstroom. ZA
  • du Preez, Jan L.; North-West University. Faculty of Health Sciences. Centre of Excellence for Pharmaceutical Sciences. Potchefstroom. ZA
  • van Zyl, Sterna; North-West University. Faculty of Health Sciences. Centre of Excellence for Pharmaceutical Sciences. Potchefstroom. ZA
  • Boneschans, Banie; North-West University. Faculty of Health Sciences. Centre of Excellence for Pharmaceutical Sciences. Potchefstroom. ZA
  • du Plessis, Jeanetta; North-West University. Faculty of Health Sciences. Centre of Excellence for Pharmaceutical Sciences. Potchefstroom. ZA
Rev. bras. farmacogn ; 26(4): 521-529, July-Aug. 2016. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: lil-792699
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT The stability and the anti-ageing, skin hydrating and anti-erythema effects of a commercialized Crocodylus niloticus Laurenti, 1768, Crocodylidae, oil lotion was determined. The lotion was stored at controlled conditions over six months during which several stability tests were performed. For the clinical efficacy studies lotion was applied on volar forearm skin (female volunteers) and compared to a liquid paraffin-containing reference product. Skin hydrating and anti-ageing effects were determined with a Corneometer®, Cutometer® and Visioscan®, following single (3 h) and multiple applications (12 weeks). The Vapometer® and Mexameter® were utilized to determine this lotion's anti-erythema effects on sodium lauryl sulfate irritated skin. The lotion demonstrated good stability over 6 months. The reference product increased skin hydration and decreased skin wrinkles to a larger extent than the C. niloticus lotion after a single application, whereas the C. niloticus lotion decreased skin scaliness better than the reference product. During the long-term study, the reference product overall increased skin hydration more than the C. niloticus lotion, whereas C. niloticus lotion increased skin elasticity to a larger extent than the reference product. C. niloticus lotion increased skin wrinkles and decreased skin scaliness over 12 weeks. Compared to non-treated, irritated skin, C. niloticus lotion demonstrated some potential anti-inflammatory characteristics.

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: Rev. bras. farmacogn Assunto da revista: Farmácia Ano de publicação: 2016 Tipo de documento: Artigo / Documento de projeto País de afiliação: África do Sul Instituição/País de afiliação: North-West University/ZA

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: Rev. bras. farmacogn Assunto da revista: Farmácia Ano de publicação: 2016 Tipo de documento: Artigo / Documento de projeto País de afiliação: África do Sul Instituição/País de afiliação: North-West University/ZA
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