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Association study in Alzheimer’s disease of single nucleotide polymorphisms implicated with coffee consumption
Yamamoto, Victor Junji; Paula, Vanessa de Jesus Rodrigues de; Forlenza, Orestes Vicente; Santos, Bernardo dos; Kerr, Daniel Shikanai.
Afiliação
  • Yamamoto, Victor Junji; University of Sao Paulo. Faculty of Medicine. Department and Institute of Psychiatry. São Paulo. BR
  • Paula, Vanessa de Jesus Rodrigues de; University of Sao Paulo. Faculty of Medicine. Department and Institute of Psychiatry. São Paulo. BR
  • Forlenza, Orestes Vicente; University of Sao Paulo. Faculty of Medicine. Department and Institute of Psychiatry. São Paulo. BR
  • Santos, Bernardo dos; University of Sao Paulo. School of Nursing. Research Assistance Service. São Paulo. BR
  • Kerr, Daniel Shikanai; University of Sao Paulo. Faculty of Medicine. Department and Institute of Psychiatry. São Paulo. BR
Rev. psiquiatr. clín. (São Paulo) ; 42(3): 69-73, May-Jun/2015. ilus, tab, graf
Artigo em Inglês | LILACS | ID: lil-797117
Biblioteca responsável: BR66.1
ABSTRACT
There is evidence from animal and in vitro models of the protective effects of caffeine in Alzheimer’s disease. The suggested mechanisms through which caffeine may protect neurons against Alzheimer’s disease pathology include the facilitation of beta-amyloid clearance, upregulation of cholinergic transmission, and increased neuronal plasticity and survival. Epidemiological studies support that Alzheimer’s disease patients consume smaller amounts of coffee beverages throughout their lives as compared to age-matched cognitively healthy individuals.

Objective:

The aim of the present study was to determine whether the negative association between Alzheimer’s disease and coffee consumption may be influenced by a common genetic predisposition, given the fact that the pattern of coffee consumption is determined by both environmental and genetic factors.

Method:

We conducted an in silico search addressing the association between genetic polymorphisms related to coffee consumption and the diagnosis of Alzheimer’s disease. We further investigated the interactions between genes located in regions bearing these polymorphisms.

Results:

Our analysis revealed no evidence for a genetic association (nor interaction between related proteins) involving coffee consumption and Alzheimer’s disease.

Discussion:

The negative association between Alzheimer’s disease and coffee consumption suggested by epidemiological studies is most likely due to environmental factors that are not necessarily regulated by genetic background...
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Polimorfismo Genético / Cafeína / Doença de Alzheimer Limite: Feminino / Humanos Idioma: Inglês Revista: Rev. psiquiatr. clín. (São Paulo) Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: University of Sao Paulo/BR

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Polimorfismo Genético / Cafeína / Doença de Alzheimer Limite: Feminino / Humanos Idioma: Inglês Revista: Rev. psiquiatr. clín. (São Paulo) Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: University of Sao Paulo/BR
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