Role of ultrasound for Down syndrome screening in advanced maternal age.
Am J Obstet Gynecol
; 185(5): 1028-31, 2001 Nov.
Article
em En
| MEDLINE
| ID: mdl-11717626
ABSTRACT
OBJECTIVE:
To determine the sensitivity and false-positive rate of Down syndrome screening by use of maternal serum screen and the genetic sonogram in women > or =35 years of age. STUDYDESIGN:
We searched our perinatal databases retrospectively from January 1992 to January 2000 for the following criteria known Down syndrome fetus or newborn, advanced maternal age, and genetic sonogram from 14-24 weeks' gestation. The a priori maternal age or maternal serum screen risk was modified by likelihood ratios for ultrasound markers. Without markers the risk was reduced by 50%. The cut-off was 1270.RESULTS:
Age and maternal serum screen had a sensitivity of 90.5% and a false-positive rate of 27.1%. Age and ultrasound had a 95.2% sensitivity and 43.5% false-positive rate, whereas the combination of age, maternal serum screen, and ultrasound had a 97.6% sensitivity and a 22.0% false-positive rate.CONCLUSION:
The combination of age, maternal serum screen, and ultrasound improves the sensitivity for Down syndrome detection in the advanced maternal age population.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Programas de Rastreamento
/
Ultrassonografia Pré-Natal
/
Idade Materna
/
Síndrome de Down
/
Gravidez de Alto Risco
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
/
Pregnancy
Idioma:
En
Revista:
Am J Obstet Gynecol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos