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Outbreak of nosocomial hepatitis C virus infection resolved by genetic analysis of HCV RNA.
J Clin Microbiol ; 40(11): 4363-6, 2002 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-12409433
In July 2000, symptomatic acute hepatitis C was diagnosed in five patients who had attended the emergency room of a municipal hospital on the same day, about 6 weeks before. Investigation of the remaining 65 patients visited at the emergency room on that day disclosed that 8 patients had a positive anti-hepatitis C virus (anti-HCV) test and 4 of them had biochemical evidence of acute anicteric hepatitis. HCV RNA was detected in 12 of the 13 anti-HCV-positive patients. Phylogenetic analysis of the nonstructural 5A (NS5A) and E2 regions showed that 10 patients, including all 9 with acute hepatitis, were infected with a closely related HCV strain, while the remaining 2 patients harbored unrelated strains. Flushing of intravenous catheters with heparin retrieved from a multidose heparin solution in saline was carried out for all the patients involved in the hepatitis outbreak but in only 1 of 23 (4%) matched controls recruited among HCV-noninfected patients attending the emergency room on the same day, and this was the only significant difference concerning risk factors for HCV infection between patients and controls. Thus, accidental contamination of a multidose heparin solution with blood from an unrecognized HCV carrier was identified as the source of this nosocomial outbreak of hepatitis C.





Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: RNA Viral / Infecção Hospitalar / Surtos de Doenças / Hepatite C / Hepacivirus Aspecto clínico: Etiologia Limite: Adulto / Idoso / Feminino / Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: J Clin Microbiol Ano de publicação: 2002 Tipo de documento: Artigo País de afiliação: Espanha