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Reduction in cardiovascular events after vascular surgery with atorvastatin: a randomized trial.
J Vasc Surg ; 39(5): 967-75; discussion 975-6, 2004 May.
Artigo em Inglês | MEDLINE | ID: mdl-15111846
ABSTRACT

OBJECTIVES:

This prospective, randomized, placebo-controlled, double-blind clinical trial was performed to analyze the effect of atorvastatin compared with placebo on the occurrence of a 6-month composite of cardiovascular events after vascular surgery. Cardiovascular complications are the most important cause of perioperative morbidity and mortality among patients undergoing vascular surgery. Statin therapy may reduce perioperative cardiac events through stabilization of coronary plaques.

METHODS:

One hundred patients were randomly assigned to receive 20 mg atorvastatin or placebo once a day for 45 days, irrespective of their serum cholesterol concentration. Vascular surgery was performed on average 30 days after randomization, and patients were prospectively followed up over 6 months. The cardiovascular events studied were death from cardiac cause, nonfatal myocardial infarction, unstable angina, and stroke.

RESULTS:

Fifty patients received atorvastatin, and 50 received placebo. During the 6-month follow-up primary end points occurred in 17 patients, 4 in the atorvastatin group and 13 in the placebo group. The incidence of cardiac events was more than three times higher with placebo (26.0%) compared with atorvastatin (8.0%; P =.031). The risk for an event was compared between the groups with the Kaplan-Meier method, as event-free survival after vascular surgery. Patients given atorvastatin exhibited a significant decrease in the rate of cardiac events, compared with the placebo group, within 6 months after vascular surgery (P =.018).

CONCLUSION:

Short-term treatment with atorvastatin significantly reduces the incidence of major adverse cardiovascular events after vascular surgery.
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Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Pirróis / Procedimentos Cirúrgicos Vasculares / Doenças Cardiovasculares / Inibidores de Hidroximetilglutaril-CoA Redutases / Ácidos Heptanoicos Tipo de estudo: Primary_study Aspecto clínico: Etiologia / Prognóstico / Terapia Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: J Vasc Surg Assunto da revista: Angiologia Ano de publicação: 2004 Tipo de documento: Artigo País de afiliação: Brasil